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Sökning: onr:"swepub:oai:DiVA.org:uu-108371" > Run-off replication...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003618naa a2200433 4500
001oai:DiVA.org:uu-108371
003SwePub
008090917s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1083712 URI
0247 a https://doi.org/10.1371/journal.pgen.10005462 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Berglund, Eva C.u Uppsala universitet,Molekylär evolution4 aut
2451 0a Run-off replication of host-adaptability genes is associated with gene transfer agents in the genome of mouse-infecting Bartonella grahamii
264 c 2009-07-03
264 1b Public Library of Science (PLoS),c 2009
338 a print2 rdacarrier
520 a The genus Bartonella comprises facultative intracellular bacteria adapted to mammals, including previously recognized and emerging human pathogens. We report the 2,341,328 bp genome sequence of Bartonella grahamii, one of the most prevalent Bartonella species in wild rodents. Comparative genomics revealed that rodent-associated Bartonella species have higher copy numbers of genes for putative host-adaptability factors than the related human-specific pathogens. Many of these gene clusters are located in a highly dynamic region of 461 kb. Using hybridization to a microarray designed for the B. grahamii genome, we observed a massive, putatively phage-derived run-off replication of this region. We also identified a novel gene transfer agent, which packages the bacterial genome, with an over-representation of the amplified DNA, in 14 kb pieces. This is the first observation associating the products of run-off replication with a gene transfer agent. Because of the high concentration of gene clusters for host-adaptation proteins in the amplified region, and since the genes encoding the gene transfer agent and the phage origin are well conserved in Bartonella, we hypothesize that these systems are driven by selection. We propose that the coupling of run-off replication with gene transfer agents promotes diversification and rapid spread of host-adaptability factors, facilitating host shifts in Bartonella.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a Biology
653 a Biologi
7001 a Frank, A. Carolinu Uppsala universitet,Molekylär evolution4 aut
7001 a Calteau, Alexandrau Uppsala universitet,Molekylär evolution4 aut
7001 a Vinnere Pettersson, Olgau Uppsala universitet,Molekylär evolution4 aut
7001 a Granberg, Fredriku Uppsala universitet,Molekylär evolution4 aut
7001 a Eriksson, Ann-Sofieu Uppsala universitet,Molekylär evolution4 aut
7001 a Näslund, Kristinau Uppsala universitet,Molekylär evolution4 aut
7001 a Holmberg, Martinu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)martholm
7001 a Lindroos, Hilleviu Uppsala universitet,Molekylär evolution4 aut
7001 a Andersson, Siv G. E.u Uppsala universitet,Molekylär evolution4 aut0 (Swepub:uu)san07069
7102 a Uppsala universitetb Molekylär evolution4 org
7730 t PLoS geneticsd : Public Library of Science (PLoS)g 5:7, s. e1000546-q 5:7<e1000546-x 1553-7404
8564 u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000546&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108371
8564 8u https://doi.org/10.1371/journal.pgen.1000546

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