Sökning: onr:"swepub:oai:DiVA.org:uu-108379" > Genome dynamics of ...
Fältnamn | Indikatorer | Metadata |
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000 | 03690naa a2200397 4500 | |
001 | oai:DiVA.org:uu-108379 | |
003 | SwePub | |
008 | 090917s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1083792 URI |
024 | 7 | a https://doi.org/10.1186/1471-2164-11-1522 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berglund, Eva C.u Uppsala universitet,Molekylär evolution4 aut |
245 | 1 0 | a Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents |
264 | c 2010-03-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
520 | a Background: Rodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the most prevalent blood-borne bacteria in wild rodents, revealed a higher abundance of genes for host-cell interaction systems than in the genomes of closely related human pathogens. The sequence variability within the global B. grahamii population was recently investigated by multi locus sequence typing, but no study on the variability of putative host-cell interaction systems has been performed. Results: To study the population dynamics of B. grahamii, we analyzed the genomic diversity on a whole-genome scale of 27 B. grahamii strains isolated from four different species of wild rodents in three geographic locations separated by less than 30 km. Even using highly variable spacer regions, only 3 sequence types were identified. This low sequence diversity contrasted with a high variability in genome content. Microarray comparative genome hybridizations identified genes for outer surface proteins, including a repeated region containing the fha gene for filamentous hemaggluttinin and a plasmid that encodes a type IV secretion system, as the most variable. The estimated generation times in liquid culture medium for a subset of strains ranged from 5 to 22 hours, but did not correlate with sequence type or presence/absence patterns of the fha gene or the plasmid. Conclusion: Our study has revealed a geographic microstructure of B. grahamii in wild rodents. Despite near-identity in nucleotide sequence, major differences were observed in gene presence/absence patterns that did not segregate with host species. This suggests that genetically similar strains can infect a range of different hosts. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a Biology | |
653 | a Biologi | |
700 | 1 | a Ehrenborg, Christianu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)chriehre |
700 | 1 | a Vinnere Pettersson, Olgau Uppsala universitet,Molekylär evolution4 aut |
700 | 1 | a Granberg, Fredriku Uppsala universitet,Molekylär evolution4 aut |
700 | 1 | a Näslund, Kristinau Uppsala universitet,Molekylär evolution4 aut |
700 | 1 | a Holmberg, Martinu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)martholm |
700 | 1 | a Andersson, Siv G. E.u Uppsala universitet,Molekylär evolution4 aut0 (Swepub:uu)san07069 |
710 | 2 | a Uppsala universitetb Molekylär evolution4 org |
773 | 0 | t BMC Genomicsd : Springer Science and Business Media LLCg 11, s. 152-q 11<152-x 1471-2164 |
856 | 4 | u https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/1471-2164-11-152 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108379 |
856 | 4 8 | u https://doi.org/10.1186/1471-2164-11-152 |
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