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PTFE bypass or thru...
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Lepäntalo, M.
(författare)
PTFE bypass or thrupass for superficial femoral artery occlusion? : A randomised controlled trial
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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Elsevier BV,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-110116
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110116URI
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https://doi.org/10.1016/j.ejvs.2009.01.003DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Early results of a thrupass endograft in the treatment of femoral lesions are promising. Less morbidity and better cost-effectiveness are suggested to be achieved in the treatment of chronic lower limb ischaemia with endovascular treatment compared to surgical treatment. PATIENTS AND METHODS: This randomised multicentre trial aimed to enroll a group of 60+60 patients for the treatment of 5-25-cm occlusions of superficial femoral artery (SFA) to be followed up for 3 years. Patients were treated either with endoluminal PTFE thrupass (WL Gore & Ass) or with surgical polytetrafluoroethylene (PTFE) bypass to proximal popliteal artery. Primary patency at 3 years was scheduled to be the primary end-point and secondary patency, functional success, costs and quality of life the secondary end-points. RESULTS: A sample of 100 consecutive SFA occlusions in one of the centres revealed that only 4% of the lesions were amenable for the study. The trial was prematurely terminated due to the results of an interim analysis at the time when 44 patients were recruited: the 1-year primary patency (excluding technical failures) was 48% for thrupass and 95% for bypass (p=0.02). The patency difference in favour of surgical bypass over endovascular thrupass was also sustained after completion of 1-year follow-up, the primary patencies being 46% and 84% at 1 year with grossly equilinear life-table curves thereafter (p=0.18), respectively. The corresponding secondary patencies were 63% and 100% (p=0.05) when excluding technical failures and 58% and 100% (p=0.02) according to intention-to-treat analysis. Secondary outcomes were thus not analysed. CONCLUSION: Treatment of SFA occlusions (TASC IIB and C or Imelda Ia and II) should be done by PTFE bypass rather than by PTFE thrupass, as thrupass is connected with worse early outcome. These results represent only a small category of femoral disease.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Laurila, K.
(författare)
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Roth, W-D.
(författare)
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Rossi, P.
(författare)
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Lavonen, J.
(författare)
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Mäkinen, K.
(författare)
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Manninen, H.
(författare)
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Romsi, P.
(författare)
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Perälä, J.
(författare)
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Bergqvist, DavidUppsala universitet,Kärlkirurgi(Swepub:uu)daviberg
(författare)
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Uppsala universitetKärlkirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Vascular and Endovascular Surgery: Elsevier BV37:5, s. 578-5841078-58841532-2165
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Till lärosätets databas
- Av författaren/redakt...
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Lepäntalo, M.
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Laurila, K.
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Roth, W-D.
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Rossi, P.
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Lavonen, J.
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Mäkinen, K.
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visa fler...
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Manninen, H.
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Romsi, P.
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Perälä, J.
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Bergqvist, David
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visa färre...
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European Journal ...
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Uppsala universitet