Sökning: onr:"swepub:oai:DiVA.org:uu-111314" >
Bileopancreatic Div...
Bileopancreatic Diversion with Duodenal Switch lowers both Early and Late Phases of Glucose, Insulin and Proinsulin responses after Meal
-
- Johansson, Hans-Erik, 1960- (författare)
- Uppsala universitet,Geriatrik
-
- Hänni, Arvo (författare)
- Uppsala universitet,Geriatrik
-
- Karlsson, F. Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism
-
visa fler...
-
- Edén-Engström, Britt (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism
-
- Öhrvall, Margareta (författare)
- Uppsala universitet,Geriatrik
-
- Sundbom, Magnus (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
-
- Zethelius, Björn (författare)
- Uppsala universitet,Geriatrik
-
visa färre...
-
(creator_code:org_t)
- 2010-03-03
- 2010
- Engelska.
-
Ingår i: Obesity Surgery. - : Springer Science and Business Media LLC. - 0960-8923 .- 1708-0428. ; 20:5, s. 549-558
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Hyperproinsulinemia is associated with obesity and type 2 diabetes. We explored the after-meal dynamics of proinsulin and insulin and postprandial effects on glucose and lipids in patients treated with bileopancreatic diversion with duodenal switch (BPD-DS) surgery compared with normal-weight controls [body mass index (BMI)+/- SD, 23.2 +/- 2.4 kg/m(2)].Ten previously morbidly obese (BMI +/- SD, 53.5 +/- 3.8 kg/m(2)) patients free from diabetes who had undergone BPD-DS (BMI +/- SD, 29.0 +/- 5.2 kg/m(2)) 2 years earlier were recruited. A standardised meal (2400 kJ) was ingested, and glucose, proinsulin, insulin, free fatty acids and triglycerides (TGs) were determined during 180 min. Follow-up characteristics yearly on glucose, lipids, creatinine and uric acid over 3 years after BPD-DS are presented.Fasting glucose and insulin were lower, 0.4 mmol/L and 4.6 pmol/L, respectively, in the BPD-DS group despite higher BMI. Fasting proinsulin was similar in both groups. Postprandial area under the curve (AUC) for glucose, proinsulin and insulin did not differ between the two groups (p = 0.106-734). Postprandial changes in glucose, proinsulin and insulin were essentially similar but absolute concentrations of proinsulin and insulin were lower in the later phases in the BPD-DS group (p = 0.052-0.001). Postprandial AUC for TGs was lower in the BPD-DS group (p = 0.005). Postprandial changes in TGs were lowered in the intermediate phase (p = 0.07-0.08) and in the late phase (0.002). Follow-up data showed markedly lowered creatinine and uric acid after BPD-DS.BPD-DS surgery induces a large weight loss and lowers, close to normal, postprandial responses of glucose, proinsulin and insulin but with marked lowering of TGs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Proinsulin; Insulin; Obesity; Bileopancreatic diversion with duodenal switch
- Endocrinology
- Endokrinologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas