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Neural crest stem c...
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Olerud, JohanUppsala universitet,Institutionen för medicinsk cellbiologi
(författare)
Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-10-13
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Springer Science and Business Media LLC,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-111981
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111981URI
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https://doi.org/10.1007/s00125-009-1544-zDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AIMS/HYPOTHESIS: Long-term graft survival after islet transplantation to patientswith type 1 diabetes is insufficient, necessitating the development of newstrategies to enhance transplant viability. Here we investigated whetherco-transplantation of neural crest stem cells (NCSCs) with islets improves islet survival and function in normoglycaemic and diabetic mice. METHODS: Islets alone or together with NCSCs were transplanted under the kidney capsule tonormoglycaemic or alloxan-induced diabetic mice. Grafts were analysed for size,proliferation, apoptosis and insulin release. In diabetic recipients bloodglucose levels were examined before and after graft removal. RESULTS: In mixedtransplants NCSCs actively migrated and extensively associated withco-transplanted pancreatic islets. Proliferation of beta cells was markedlyincreased and transplants displayed improved insulin release in normoglycaemicmice compared with those receiving islet-alone transplants. Mixed grafts survivedsuccessfully and partially restored normoglycaemia in alloxan-induced diabeticmice. CONCLUSIONS/INTERPRETATION: Co-grafting of NCSCs with pancreatic isletsimproved insulin release in mixed transplants and enhanced beta cellproliferation, resulting in increased beta cell mass. This co-transplantationmodel offers an opportunity to restore neural-islet interactions and improveislet functions after transplantation.
Ämnesord och genrebeteckningar
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Diabetes
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Islets of Langerhans
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Neural stem cells
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Transplantation
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Trophic factor
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MEDICINE
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MEDICIN
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Sandberg, MonicaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)mosan330
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Jansson, LeifUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)leifjans
(författare)
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Kozlova, Elena,1956-Uppsala universitet,Neuroanatomi,Neuroanatomy(Swepub:uu)elenkozl
(författare)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer Science and Business Media LLC52:12, s. 2594-26010012-186X1432-0428
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