Sökning: onr:"swepub:oai:DiVA.org:uu-112124" >
GeneFinder: "in sil...
GeneFinder: "in silico" positional cloning of trait genes
-
- Martinez Barrio, Alvaro, 1977- (författare)
- Uppsala universitet,Centrum för bioinformatik,Bongcam-Rudloff
-
- Feifei, Xu (författare)
- Uppsala universitet,Institutionen för evolution, genomik och systematik,Molekylär evolution
-
- Lagercrantz, Erik (författare)
- Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff
-
visa fler...
-
- Bongcam-Rudloff, Erik (författare)
- Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff
-
visa färre...
-
(creator_code:org_t)
- Engelska.
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Motivation: Positional cloning of trait genes is extremely laborious and the amount of information available on gene function in different organisms is increasing so rapidly that it is hard for a research group to collect all the relevant information from a number of data sources without performing a large number of manual and time consuming searches. Results: A web service application named GeneFinder was designed and implemented. It collects selected available information related to trait loci within a given chromosomal region that control a specific phenotype. The information contains details on gene function, disease conditions, tissue expression as well as predicted gene homologies in several other species. The information gathered is further ordered by a special-purpose ranking algorithm. A web interface to the GeneFinder web service was also developed where the results are presented in a ranked list easing its interpretation. We explain the design of the architecture, show how our web interface works, and finally test a candidate region. Availability: GeneFinder is publicly available and free to use. The web interface is available at http://www.genefinder.org/.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- data integration
- web services
- GWAS
- genome-wide association studies
- Molecular medicine (genetics and pathology)
- Molekylär medicin (genetik och patologi)
- Bioinformatics
- Bioinformatik
- Medical Genetics
- medicinsk genetik
Publikations- och innehållstyp
- pop (ämneskategori)
- ovr (ämneskategori)