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Enrichment of brain...
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Kemkemer, Claus
(författare)
Enrichment of brain-related genes on the mammalian X chromosome is ancient and predates the divergence of synapsid and sauropsid lineages
- Artikel/kapitelEngelska2009
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2009-09-04
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Springer Science and Business Media LLC,2009
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-112613
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112613URI
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https://doi.org/10.1007/s10577-009-9072-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Previous studies have revealed an enrichment of reproduction- and brain-related genes on the human X chromosome. In the present study, we investigated the evolutionary history that underlies this functional specialization. To do so, we analyzed the orthologous building blocks of the mammalian X chromosome in the chicken genome. We used Affymetrix chicken genome microarrays to determine tissue-selective gene expression in several tissues of the chicken, including testis and brain. Subsequently, chromosomal distribution of genes with tissue-selective expression was determined. These analyzes provided several new findings. Firstly, they showed that chicken chromosomes orthologous to the mammalian X chromosome exhibited an increased concentration of genes expressed selectively in brain. More specifically, the highest concentration of brain-selectively expressed genes was found on chicken chromosome GGA12, which shows orthology to the X chromosomal regions with the highest enrichment of non-syndromic X-linked mental retardation (MRX) genes. Secondly, and in contrast to the first finding, no enrichment of testis-selective genes could be detected on these chicken chromosomes. These findings indicate that the accumulation of brain-related genes on the prospective mammalian X chromosome antedates the divergence of sauropsid and synapsid lineages 315 million years ago, whereas the accumulation of testis-related genes on the mammalian X chromosome is more recent and due to adaptational changes.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kohn, Matthias
(författare)
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Kehrer-Sawatzki, Hildegard
(författare)
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Fundele, Reinald HUppsala universitet,Zoologisk utvecklingsbiologi(Swepub:uu)refu535
(författare)
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Hameister, Horst
(författare)
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Uppsala universitetZoologisk utvecklingsbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Chromosome Research: Springer Science and Business Media LLC17:6, s. 811-8200967-38491573-6849
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