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Geographical preval...
Geographical prevalence, risk factors and impact of hepatitis B and C after renal transplantation
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Kliem, V (författare)
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Michel, U (författare)
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Burg, M (författare)
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visa fler...
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Bock, A (författare)
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Chapman, J (författare)
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Dussol, B (författare)
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Fritsche, L (författare)
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Lebranchu, Y (författare)
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Oppenheimer, F (författare)
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Pohanka, E (författare)
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Salvadori, M (författare)
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- Tufveson, Gunnar (författare)
- Uppsala universitet,Transplantationskirurgi
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visa färre...
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Clinical Nephrology. - 0301-0430. ; 71:4, s. 423-429
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- BACKGROUND: Hepatitis B (HBV) and hepatitis C (HCV) virus infections are major risk factors affecting long-term morbidity and mortality after renal transplantation. Hepatitis prevalence is subject to geographical variations. OBJECTIVE: To compare and analyze the geographical prevalence, risk factors and impact of HBV and HCV infection in multinational cohorts of renal transplant recipients. METHODS: From 1989 - 2002, data on 12,856 kidney transplant recipients in 37 countries were collected within the prospective MOST (Multinational Observational Study in Transplantation). Subgroup analyses of hepatitis-related prevalence, risk factors and impact were conducted on patients whose HBV and HCV status was available at time of transplantation. Countries were substratified according to population prevalence of > or = 5% HBV or > or = 10% HCV. RESULTS: The prevalence of HBV was 2.9%, of HCV 8.7% and of HBV together with HCV 0.4%. Risk factors for hepatitis infection in renal transplant recipients were long dialysis time, retransplantation and blood transfusions. At each study endpoint up to 5 years after transplantation, no significant differences in graft function were observed, although the 1-year acute rejection rate tended to be lower in HCV+ patients. At 5 years post-transplant, there were no differences between the subgroups and regions regarding infections, post-transplant diabetes mellitus or malignancies including PTLD. CONCLUSIONS: Overall, HCV infections are more prevalent than HBV. Despite large geographical differences in prevalence, HBV and HCV status did not appear to have a significant impact on renal graft function, infections, malignancies and post-transplant diabetes mellitus up to 5 years after renal transplantation throughout the MOST countries.
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- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kliem, V
-
Michel, U
-
Burg, M
-
Bock, A
-
Chapman, J
-
Dussol, B
-
visa fler...
-
Fritsche, L
-
Lebranchu, Y
-
Oppenheimer, F
-
Pohanka, E
-
Salvadori, M
-
Tufveson, Gunnar
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visa färre...
- Artiklar i publikationen
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Clinical Nephrol ...
- Av lärosätet
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Uppsala universitet