Sökning: onr:"swepub:oai:DiVA.org:uu-11760" >
Young maternal age ...
Young maternal age at delivery is associated with asthma in adult offspring
-
Laerum, Birger N (författare)
-
Svanes, Cecilie (författare)
-
Wentzel-Larsen, Tore (författare)
-
visa fler...
-
Gulsvik, Amund (författare)
-
- Torén, Kjell, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, Department of Internal Medicine,Institute of Medicine, School of Public Health and Community Medicine
-
- Norrman, Eva (författare)
- Umeå universitet,Lungmedicin
-
Gíslason, Thorarinn (författare)
-
- Janson, Christer (författare)
- Uppsala universitet,Lungmedicin och allergologi
-
Omenaas, Ernst (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
-
Ingår i: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 101:7, s. 1431-1438
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
http://www.resmedjou...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Some studies have shown an association between lower maternal age at delivery and increased asthma in children and young adults. It is unclear whether this represents an effect of maternal ageing or a protective effect of siblings. In a North-European population based study, we investigated whether mother's age at delivery was associated with risk for asthma and hay fever in adult offspring, taking into account relevant confounders. Methods: A total of 16,190 subjects (74%) aged 23-54yr answered a postal questionnaire in a follow-up of the European Community Respiratory Health Survey (ECRHS I). Results: The associations of maternal age at delivery with hay fever, respiratory symptoms and diagnosed asthma were analysed using logistic regression, adjusting for household size, dwelling, parental education, centre, gender, adult hay fever, smoking, age and body mass index (BMI). The adjusted odds ratios (95% CI) for wheeze with breathlessness, wheeze without a cold and asthma in the offspring were 0.94 (0.90-0.99), 0.89 (0.86-0.94) and 0.92 (0.88-0.97), respectively, per 5yr increase in maternal age. No heterogeneity between centres was found (p = 0.84). The estimates remained similar in sub-sample analyses when adjusting for siblings, maternal smoking (n = 3109) and for birth weight (n = 1686). Hay fever was more common among those with the youngest and oldest mothers. Conclusions: In this large North-European multi-centre study, asthma was less common with increasing maternal age. This effect was consistent between centres and persisted with adjustment for several potential confounders, suggesting that the association may possibly be explained by biological changes related to maternal ageing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Lung disease
- Bronchus disease
- Immunopathology
- Nose disease
- ENT disease
- Obstructive pulmonary disease
- Respiratory disease
- Human
- Pneumology
- Progeny
- Adult
- Association
- Delivery
- Maternal age
- Allergy
- Rhinitis
- Asthma
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Laerum, Birger N
-
Svanes, Cecilie
-
Wentzel-Larsen, ...
-
Gulsvik, Amund
-
Torén, Kjell, 19 ...
-
Norrman, Eva
-
visa fler...
-
Gíslason, Thorar ...
-
Janson, Christer
-
Omenaas, Ernst
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
Respiratory Medi ...
- Av lärosätet
-
Uppsala universitet
-
Umeå universitet
-
Göteborgs universitet