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The effect of decon...
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Kumar, V V P
(författare)
The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-07-15
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Springer Science and Business Media LLC,2009
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-120654
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120654URI
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https://doi.org/10.1038/clpt.2009.114DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration-time points from 76 venlafaxine overdose events (median dose 2,625 (150-13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. The data were modeled using WinBUGS (Windows Bayesian Inference Using Gibbs Sampling). A one-compartment model with first-order input and elimination provided an adequate description of the data. SDAC increased clearance (CL) of venlafaxine by 35%, and SDAC and WBI combined reduced the fraction absorbed by 29%. However, the latter produced a greater reduction in maximum plasma concentration (C(max)) for a similar drop in area under the plasma concentration-time curve (AUC). Both SDAC alone, and a combination of SDAC and WBI, decreased the AUC after venlafaxine overdose, but the combination may be more beneficial because it reduces peak concentrations to a greater extent.
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Oscarsson, S.Uppsala universitet,Institutionen för farmaceutisk biovetenskap
(författare)
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Friberg, L .E.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri(Swepub:uu)lenasimo
(författare)
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Isbister, G K
(författare)
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Hackett, L P
(författare)
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Duffull, S B
(författare)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Pharmacology and Therapeutics: Springer Science and Business Media LLC86:4, s. 403-4100009-92361532-6535
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