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Low dietary intake ...
Low dietary intake of beta-carotene, alpha-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort
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- Helmersson, Johanna (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Research and Development, County Council of Gävleborg/Uppsala University, Gävle Hospital, Sweden
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- Ärnlöv, Johan (författare)
- Uppsala universitet,Geriatrik,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism/Geriatrics, Faculty of Medicine, Uppsala University, Uppsala Science Park, Sweden
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi,Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, Sweden
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- Basu, Samar (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism/Geriatrics, Faculty of Medicine, Uppsala University, Uppsala Science Park; Center of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Cambridge University Press, 2009
- 2009
- Engelska.
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Ingår i: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 101:12, s. 1775-1782
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Fruit and vegetable consumption has been associated with a reduced risk of several diseases including CVD. A part of these effects seen could be linked to anti-inflammatory and antioxidative effects, although this has not been thoroughly investigated. The present study was designed to investigate the effects of the dietary intake of beta-carotene, alpha-tocopherol and ascorbic acid on in vivo biomarkers of inflammation (PGF2alpha, high-sensitive C-reactive protein (hsCRP) and IL-6 formation) and oxidative stress (F2-isoprostane formation), the two important factors associated with accelerated atherosclerosis. The dietary intake of 704 participants in the Uppsala Longitudinal Study of Adult Men (ULSAM) at age 70 years was registered and inflammatory and oxidative stress biomarkers were quantified 7 years later. The registered dietary intakes of ascorbic acid and alpha-tocopherol were negatively associated linearly and in quartiles with both PGF2alpha, hsCRP, IL-6 and F2-isoprostanes, where ascorbic acid intake generally was more strongly associated. Dietary intake of beta-carotene was only significantly negatively associated with F2-isoprostanes. In conclusion, the present study is the first to suggest that the intake of food rich in antioxidants is associated with reduced cyclo-oxygenase- and cytokine-mediated inflammation and oxidative stress at 7 years of follow-up. These associations could be linked to the beneficial effects of fruit and vegetables observed on CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Antioxidants
- Prostaglandins
- Inflammation
- Oxidative stress
- Isoprostanes
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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