Sökning: onr:"swepub:oai:DiVA.org:uu-120870" >
Growth-differentiat...
Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly : results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
-
- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
-
- Kempf, Tibor (författare)
- Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
-
visa fler...
-
- Tapken, Heike (författare)
- Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
-
- Quint, Anja (författare)
- Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
-
- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
-
- Olofsson, Sylvia, 1955- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
-
- Venge, Per (författare)
- Uppsala universitet,Klinisk kemi
-
- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
-
- Hulthe, Johannes (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Elmgren, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Wollert, Kai C (författare)
-
visa färre...
-
(creator_code:org_t)
- 2009-06-26
- 2009
- Engelska.
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 30:19, s. 2346-2353
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- AIMS: Growth-differentiation factor-15 (GDF-15) is emerging as an independent prognostic biomarker in patients with cardiovascular (CV) disease. Little is known about the pathophysiological basis for the close association of GDF-15 to future CV events. We hypothesized that GDF-15 is related to underlying CV pathologies. METHODS AND RESULTS: To relate the levels of GDF-15 to indices of CV dysfunction and disease in elderly individuals, serum levels of GDF-15 were measured in 1004 subjects aged 70 years from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Carotid intima-media thickness and plaque burden, and left ventricular (LV) geometry and function were assessed by ultrasound. Endothelial function was evaluated in forearm resistance vessels and in the brachial artery by venous occlusion plethysmography and ultrasound imaging, respectively. Elevated levels of GDF-15 were related to several CV risk factors (male gender, current smoking, body mass index, waist circumference, diabetes, fasting glucose, triglycerides, and low HDL cholesterol). After adjustment for CV risk factors, increased levels of GDF-15 were associated with reduced endothelium-dependent vasodilation in resistance vessels, plaque burden, LV mass and concentric LV hypertrophy, reduced LV ejection fraction, and clinical manifestations of coronary artery disease and heart failure. CONCLUSION: GDF-15 carries information on CV dysfunction and disease that is not captured by traditional CV risk factors in elderly individuals.
Nyckelord
- GDF-15
- Biomarker
- Endothelial function
- Atherosclerosis
- Hypertrophy
- Heart failure
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lind, Lars
-
Wallentin, Lars, ...
-
Kempf, Tibor
-
Tapken, Heike
-
Quint, Anja
-
Lindahl, Bertil, ...
-
visa fler...
-
Olofsson, Sylvia ...
-
Venge, Per
-
Larsson, Anders
-
Hulthe, Johannes
-
Elmgren, Anders
-
Wollert, Kai C
-
visa färre...
- Artiklar i publikationen
-
European Heart J ...
- Av lärosätet
-
Uppsala universitet