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Simultaneous optima...
Simultaneous optimal experimental design on dose and sample times
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- Nyberg, Joakim (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri
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- Karlsson, Mats O. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri
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- Hooker, Andrew C. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri
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(creator_code:org_t)
- 2009-03-25
- 2009
- Engelska.
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Ingår i: Journal of Pharmacokinetics and Pharmacodynamics. - : Springer Science and Business Media LLC. - 1567-567X .- 1573-8744. ; 36:2, s. 125-145
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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visa färre...
Abstract
Ämnesord
Stäng
- Optimal experimental design can be used for optimizing new pharmacokinetic (PK)-pharmacodynamic (PD) studies to increase the parameter precision. Several methods for optimizing non-linear mixed effect models has been proposed previously but the impact of optimizing other continuous design parameters, e.g. the dose, has not been investigated to a large extent. Moreover, the optimization method (sequential or simultaneous) for optimizing several continuous design parameters can have an impact on the optimal design. In the sequential approach the time and dose where optimized in sequence and in the simultaneous approach the dose and time points where optimized at the same time. To investigate the sequential approach and the simultaneous approach; three different PK-PD models where considered. In most of the cases the optimization method did change the optimal design and furthermore the precision was improved with the simultaneous approach.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Optimal design
- simultaneous optimization
- dose optimization
- pharmacometrics
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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