Sökning: onr:"swepub:oai:DiVA.org:uu-122921" > A polymorphism with...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03204naa a2200577 4500 | |
001 | oai:DiVA.org:uu-122921 | |
003 | SwePub | |
008 | 100421s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1229212 URI |
024 | 7 | a https://doi.org/10.1002/art.246582 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Webb, Ryan4 aut |
245 | 1 0 | a A polymorphism within IL21R confers risk for systemic lupus erythematosus |
264 | 1 | b Wiley,c 2009 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: Interleukin-21 (IL-21) is a member of the type I cytokine superfamily that has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models. We recently reported that polymorphisms within the IL21 gene are associated with increased susceptibility to SLE. The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE. METHODS: We genotyped 17 SNPs in the IL21R gene in 2 large cohorts of lupus patients (a European-derived cohort and a Hispanic cohort) and in ethnically matched healthy controls. RESULTS: We identified and confirmed the association between rs3093301 within the IL21R gene and SLE in the 2 cohorts (meta-analysis odds ratio 1.16 [95% confidence interval 1.08-1.25], P=1.0x10(-4)). CONCLUSION: Our findings indicate that IL21R is a novel susceptibility gene for SLE. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Merrill, Joan T4 aut |
700 | 1 | a Kelly, Jennifer A4 aut |
700 | 1 | a Sestak, Andrea4 aut |
700 | 1 | a Kaufman, Kenneth M4 aut |
700 | 1 | a Langefeld, Carl D4 aut |
700 | 1 | a Ziegler, Julie4 aut |
700 | 1 | a Kimberly, Robert P4 aut |
700 | 1 | a Edberg, Jeffrey C4 aut |
700 | 1 | a Ramsey-Goldman, Rosalind4 aut |
700 | 1 | a Petri, Michelle4 aut |
700 | 1 | a Reveille, John D4 aut |
700 | 1 | a Alarcón, Graciela S4 aut |
700 | 1 | a Vilá, Luis M4 aut |
700 | 1 | a Alarcón-Riquelme, Marta Eu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala |
700 | 1 | a James, Judith A4 aut |
700 | 1 | a Gilkeson, Gary S4 aut |
700 | 1 | a Jacob, Chaim O4 aut |
700 | 1 | a Moser, Kathy L4 aut |
700 | 1 | a Gaffney, Patrick M4 aut |
700 | 1 | a Vyse, Timothy J4 aut |
700 | 1 | a Nath, Swapan K4 aut |
700 | 1 | a Lipsky, Peter4 aut |
700 | 1 | a Harley, John B4 aut |
700 | 1 | a Sawalha, Amr H4 aut |
710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
773 | 0 | t Arthritis and Rheumatismd : Wileyg 60:8, s. 2402-2407q 60:8<2402-2407x 0004-3591x 1529-0131 |
856 | 4 | u https://europepmc.org/articles/pmc2782592?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122921 |
856 | 4 8 | u https://doi.org/10.1002/art.24658 |
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