Sökning: onr:"swepub:oai:DiVA.org:uu-122991" > Sexually dimorphic ...
Fältnamn | Indikatorer | Metadata |
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000 | 03061naa a2200577 4500 | |
001 | oai:DiVA.org:uu-122991 | |
003 | SwePub | |
008 | 100422s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1229912 URI |
024 | 7 | a https://doi.org/10.1002/ajmg.b.309862 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fukumoto, Noriko4 aut |
245 | 1 0 | a Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease :b New data and meta-analysis |
264 | 1 | b Wiley,c 2010 |
338 | a print2 rdacarrier | |
520 | a Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these polymorphisms in a Japanese sample of 657 patients with AD and 525 controls, and obtained weak evidence of association for Val66Met (P = 0.063), but not for C270T. After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men. To confirm these observations, we collected genotyping data for each sex from 16 research centers worldwide (4,711 patients and 4,537 controls in total). The meta-analysis revealed that there was a clear sex difference in the allelic association; the Met66 allele confers susceptibility to AD in women (odds ratio = 1.14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD. | |
653 | a Alzheimer's disease (AD) | |
653 | a brain-derived neurotrophic factor (BDNF) | |
653 | a meta-analysis | |
653 | a polymorphism | |
653 | a sex difference | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Fujii, Takashi4 aut |
700 | 1 | a Combarros, Onofre4 aut |
700 | 1 | a Kamboh, M Ilyas4 aut |
700 | 1 | a Tsai, Shin-Jen4 aut |
700 | 1 | a Matsushita, Sachio4 aut |
700 | 1 | a Nacmias, Benedetta4 aut |
700 | 1 | a Comings, David E4 aut |
700 | 1 | a Arboleda, Humberto4 aut |
700 | 1 | a Ingelsson, Martinu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)maing121 |
700 | 1 | a Hyman, Bradley T4 aut |
700 | 1 | a Akatsu, Hiroyasu4 aut |
700 | 1 | a Grupe, Andrew4 aut |
700 | 1 | a Nishimura, Agnes Lumi4 aut |
700 | 1 | a Zatz, Mayana4 aut |
700 | 1 | a Mattila, Kari M4 aut |
700 | 1 | a Rinne, Juha4 aut |
700 | 1 | a Goto, Yu-ichi4 aut |
700 | 1 | a Asada, Takashi4 aut |
700 | 1 | a Nakamura, Shun4 aut |
700 | 1 | a Kunugi, Hiroshi4 aut |
710 | 2 | a Uppsala universitetb Geriatrik4 org |
773 | 0 | t American journal of medical genetics. Part B, Neuropsychiatric geneticsd : Wileyg 153B:1, s. 235-242q 153B:1<235-242x 1552-4841x 1552-485X |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122991 |
856 | 4 8 | u https://doi.org/10.1002/ajmg.b.30986 |
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