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Steroid biosynthesi...
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Do Rego, Jean-Luc
(författare)
Steroid biosynthesis within the frog brain : a model of neuroendocrine regulation
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-04-27
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Wiley,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-123967
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123967URI
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https://doi.org/10.1111/j.1749-6632.2008.03664.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [(3)H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
Ämnesord och genrebeteckningar
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eurosteroids
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brain
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neuropeptides
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neurotransmitters
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amphibians
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Seong, Jae Young
(författare)
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Burel, Delphine
(författare)
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Luu-The, Van
(författare)
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Larhammar, DanUppsala universitet,Farmakologi,Larhammar(Swepub:uu)dla05000
(författare)
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Tsutsui, Kazuyoshi
(författare)
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Pelletier, Georges
(författare)
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Tonon, Marie-Christine
(författare)
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Vaudry, Hubert
(författare)
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Uppsala universitetFarmakologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of the New York Academy of Sciences: Wiley1163, s. 83-920077-89231749-6632
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