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Insulin-heparin inf...
Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant success
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Koh, Angela (författare)
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Senior, Peter (författare)
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Salam, Abdul (författare)
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Kin, Tatsuya (författare)
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Imes, Sharleen (författare)
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Dinyari, Parastoo (författare)
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Malcolm, Andrew (författare)
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Toso, Christian (författare)
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- Nilsson, Bo (författare)
- Uppsala universitet,Enheten för klinisk immunologi
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- Korsgren, Olle (författare)
- Uppsala universitet,Enheten för klinisk immunologi
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Shapiro, A. M. James (författare)
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 89:4, s. 465-471
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited organ supply. METHODS: We examined factors that may be associated with insulin independence after islet transplantation with islets from a single donor, using univariate and multivariate analysis. RESULTS: Thirteen of 85 (15.3%) achieved insulin independence after single-donor islet transplantation. Using multivariate analysis, only the use of insulin and heparin infusions peritransplant was a significant factor associated with insulin independence, with an adjusted odds ratio of 8.6 (95% confidence interval 2.0-37.0). Patients who had received insulin and heparin infusions peritransplant had greater indices of islet engraftment and a greater reduction in insulin use (80.1% + or - 4.3% vs. 54.2% + or - 2.8%, P<0.001) even if insulin independence was not achieved. CONCLUSIONS: Peritransplant intensive insulin and heparin enhances islet transplantation outcomes likely related in part to mitigation of the effects of the instant blood-mediated inflammatory reaction, combined with islet rest and avoidance of inflammation. It would be important to further investigate the effects of peritransplant insulin and heparin infusions on islet engraftment.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Koh, Angela
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Senior, Peter
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Salam, Abdul
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Kin, Tatsuya
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Imes, Sharleen
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Dinyari, Parasto ...
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visa fler...
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Malcolm, Andrew
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Toso, Christian
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Nilsson, Bo
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Korsgren, Olle
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Shapiro, A. M. J ...
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visa färre...
- Artiklar i publikationen
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Transplantation
- Av lärosätet
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Uppsala universitet