Sökning: onr:"swepub:oai:DiVA.org:uu-124381" > Sequence variants a...
Fältnamn | Indikatorer | Metadata |
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000 | 05219naa a2201153 4500 | |
001 | oai:DiVA.org:uu-124381 | |
003 | SwePub | |
008 | 100503s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1243812 URI |
024 | 7 | a https://doi.org/10.1038/ng.3232 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gudbjartsson, Daniel F.4 aut |
245 | 1 0 | a Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
264 | c 2009-02-08 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
338 | a print2 rdacarrier | |
520 | a Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Bjornsdottir, Unnur S.4 aut |
700 | 1 | a Halapi, Eva4 aut |
700 | 1 | a Helgadottir, Anna4 aut |
700 | 1 | a Sulem, Patrick4 aut |
700 | 1 | a Jonsdottir, Gudrun M.4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Helgadottir, Hafdis4 aut |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Stefansson, Hreinn4 aut |
700 | 1 | a Williams, Carolyn4 aut |
700 | 1 | a Hui, Jennie4 aut |
700 | 1 | a Beilby, John4 aut |
700 | 1 | a Warrington, Nicole M.4 aut |
700 | 1 | a James, Alan4 aut |
700 | 1 | a Palmer, Lyle J.4 aut |
700 | 1 | a Koppelman, Gerard H.4 aut |
700 | 1 | a Heinzmann, Andrea4 aut |
700 | 1 | a Krueger, Marcus4 aut |
700 | 1 | a Boezen, H. Marike4 aut |
700 | 1 | a Wheatley, Amanda4 aut |
700 | 1 | a Altmuller, Janine4 aut |
700 | 1 | a Shin, Hyoung Doo4 aut |
700 | 1 | a Uh, Soo-Taek4 aut |
700 | 1 | a Cheong, Hyun Sub4 aut |
700 | 1 | a Jonsdottir, Brynja4 aut |
700 | 1 | a Gislason, David4 aut |
700 | 1 | a Park, Choon-Sik4 aut |
700 | 1 | a Rasmussen, Linda M.4 aut |
700 | 1 | a Porsbjerg, Celeste4 aut |
700 | 1 | a Hansen, Jakob W.4 aut |
700 | 1 | a Backer, Vibeke4 aut |
700 | 1 | a Werge, Thomas4 aut |
700 | 1 | a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn |
700 | 1 | a Jönsson, Ulla-Brittu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)ullabjon |
700 | 1 | a Ng, Maggie C. Y.4 aut |
700 | 1 | a Chan, Juliana4 aut |
700 | 1 | a So, Wing Yee4 aut |
700 | 1 | a Ma, Ronald4 aut |
700 | 1 | a Shah, Svati H.4 aut |
700 | 1 | a Granger, Christopher B.4 aut |
700 | 1 | a Quyyumi, Arshed A.4 aut |
700 | 1 | a Levey, Allan I.4 aut |
700 | 1 | a Vaccarino, Viola4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Williams, Michael J. A.4 aut |
700 | 1 | a van Rij, Andre M.4 aut |
700 | 1 | a Jones, Gregory T.4 aut |
700 | 1 | a Trabetti, Elisabetta4 aut |
700 | 1 | a Malerba, Giovanni4 aut |
700 | 1 | a Pignatti, Pier Franco4 aut |
700 | 1 | a Boner, Attilio4 aut |
700 | 1 | a Pescollderungg, Lydia4 aut |
700 | 1 | a Girelli, Domenico4 aut |
700 | 1 | a Olivieri, Oliviero4 aut |
700 | 1 | a Martinelli, Nicola4 aut |
700 | 1 | a Ludviksson, Bjorn R.4 aut |
700 | 1 | a Ludviksdottir, Dora4 aut |
700 | 1 | a Eyjolfsson, Gudmundur I.4 aut |
700 | 1 | a Arnar, David4 aut |
700 | 1 | a Thorgeirsson, Gudmundur4 aut |
700 | 1 | a Deichmann, Klaus4 aut |
700 | 1 | a Thompson, Philip J.4 aut |
700 | 1 | a Wjst, Matthias4 aut |
700 | 1 | a Hall, Ian P.4 aut |
700 | 1 | a Postma, Dirkje S.4 aut |
700 | 1 | a Gislason, Thorarinn4 aut |
700 | 1 | a Gulcher, Jeffrey4 aut |
700 | 1 | a Kong, Augustine4 aut |
700 | 1 | a Jonsdottir, Ingileif4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
710 | 2 | a Uppsala universitetb Lungmedicin och allergologi4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 41:3, s. 342-347q 41:3<342-347x 1061-4036x 1546-1718 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124381 |
856 | 4 8 | u https://doi.org/10.1038/ng.323 |
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