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Hypertension, syste...
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Margretardottir, Olof Birna
(författare)
Hypertension, systemic inflammation and body weight in relation to lung function impairment-an epidemiological study
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-09-11
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Informa UK Limited,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-124408
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124408URI
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https://doi.org/10.1080/15412550903049157DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Recent reports on the simultaneous occurrence of systemic inflammation and airflow obstruction are usually based on a highly selective patient population, but their importance warrants further evaluation in the general population. The objectives were to study the interrelationship between airflow obstruction, smoking, hypertension, obesity and CRP as a marker of systemic inflammation in a randomly selected sample of the general Icelandic population (n = 939). This study comprised 758 randomly selected men and women 40 years and older living in Reykjavik, Iceland, and who were participating in the Burden of Obstructive Lung Disease (BOLD) study (81% response rate). In addition to the BOLD protocol, which included post-bronchodilator spirometry, they answered questions about general health and medication. Serum samples were taken for measurement of C-reactive protein (CRP). In the sample-245 individuals (33%) reported having hypertension. Subjects with hypertension were older, had a higher BMI and higher CRP levels. Subjects with hypertension had lower values of FEV(1) than predicted (89.9 +/- 18.5 vs. 94.5 +/- 14.4%) (p < 0.001) and FVC (92.2 +/- 15.1 vs. 95.3 +/- 12.3%) (p = 0.002). These differences remained significant after adjusting for age, BMI, CRP and smoking. Hypertension and CRP levels above the median were both independently and additively associated with lower FEV(1) and FVC. In addition a lower FVC% was also associated with a higher BMI (> 30 mg/m2). Use of betablocking antihypertensives was not related to lung function. Hypertension, BMI and systemic inflammation affect lung function independently of each other. All three variables have a negative effect on FVC, while hypertension and high CRP were independently associated with impaired FEV(1).
Ämnesord och genrebeteckningar
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Airflow obstruction
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hypertension
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obesity
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systemic inflammation
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cytokines
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Thorleifsson, Sigurdur James
(författare)
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Gudmundsson, Gunnar
(författare)
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Olafsson, Isleifur
(författare)
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Benediktsdottir, Bryndis
(författare)
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Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn
(författare)
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Buist, A Sonia
(författare)
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Gislason, Thorarinn
(författare)
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Uppsala universitetLungmedicin och allergologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:COPD: Journal of Chronic Obstructive Pulmonary Disease: Informa UK Limited6:4, s. 250-2551541-25631541-2555
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