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ST2 and mortality i...
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Eggers, Kai M.,1962-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR
(författare)
ST2 and mortality in non-ST-segment elevation acute coronary syndrome
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Elsevier BV,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-124656
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124656URI
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https://doi.org/10.1016/j.ahj.2010.02.022DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: ST2 is a member of the interleukin-1 receptor family that is up-regulated in conditions associated with increased myocardial strain. ST2 has been shown to be independently predictive of adverse outcome in heart failure and ST-segment elevation myocardial infarction, but its prognostic value in non-ST-elevation acute coronary syndrome (NSTE-ACS) has not been established. METHODS: We measured ST2 at randomization and after 24, 48, and 72 hours in 403 NSTE-ACS patients from the GUSTO IV study, and studied its kinetics and its associations to clinical baseline factors and 1-year mortality. RESULTS: Median ST2 levels decreased from 28.4 U/mL at randomization to 21.8 U/mL at 72 hours (P < .001). Peak levels were noted 6 to 17 hours after symptom onset. Randomization ST2 levels were independently associated to N-terminal pro-B-type natriuretic peptide but otherwise exhibited only weak relations to cardiovascular risk factors and comorbidities, and biomarkers of myocardial necrosis or inflammation. ST2 was related to 1-year mortality independently of clinical risk indicators (odds ratio 2.3 [95% CI 1.1-4.6], P = .03) but lost its predictive value after additional adjustment for prognostic biomarkers, in particular N-terminal pro-B-type natriuretic peptide. CONCLUSIONS: ST2 levels are elevated early in NSTE-ACS and predict 1-year mortality. Our data indicate that ST2 represents an interesting novel pathophysiologic pathway in the setting of ischemia-related myocardial dysfunction. However, future prospective evaluations in larger populations are needed before the clinical utility of ST2 can be determined.
Ämnesord och genrebeteckningar
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Aged
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Female
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Humans
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Male
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Middle Aged
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Myocardial Infarction/*blood/mortality
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Natriuretic Peptide; Brain/*blood
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Patient Admission
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Peptide Fragments/*blood
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Prognosis
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Regression Analysis
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Risk Assessment
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Sensitivity and Specificity
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Survival Analysis
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Troponin T/*blood
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Armstrong, Paul W.
(författare)
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Califf, Robert M.
(författare)
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Simoons, Maarten L.
(författare)
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Venge, PerUppsala universitet,Klinisk kemi(Swepub:uu)pervenge
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR(Swepub:uu)larswall
(författare)
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James, Stefan K.,1964-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR(Swepub:uu)stjam367
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Heart Journal: Elsevier BV159:5, s. 788-7940002-87031097-6744
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