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Altered NK1-recepto...
Altered NK1-receptor availability in patients with post traumatic stress disorder
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- Appel, Lieuwe (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Michelgård, Åsa (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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- Linnman, Claes (författare)
- Uppsala universitet,Institutionen för psykologi
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- Fernandez, Manuel (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi
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Langström, Bengt (författare)
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- von Knorring, Lars (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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- Fredrikson, Mats (författare)
- Uppsala universitet,Institutionen för psykologi
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: [Biological Psychiatry 2009, 65(8), Suppl. 1, 118S, no. 394]. - : Elsevier BV. ; , s. 118S-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Posttraumatic stress disorder (PTSD) is an anxiety disorder that can develop after one or more traumatic events causing extreme stress or grave physical harm. The neurokinin-1 (NK1) receptor is the primary receptor for substance P (SP); a neuropeptide suggested being involved in anxiety and depression. The present study investigated differences in NK1-receptor availability between PTSD patients and healthy controls, using positron emission tomography (PET). Methods: Eleven male refugee patients (age: 41±10) with DSM-IV defined PTSD and nine healthy male control subjects (age: 33±10) were investigated using the PET-tracer [11C]GR205171, supplied by Uppsala Imanet. GR205171 is a highly selective NK1-receptor antagonist. Scans were performed during 60 minutes in the resting state. Parametric images were generated using the graphical reference Patlak method assuming irreversible binding of [11C]GR205171 from 20-60 minutes and having cerebellum as reference region. Exploratory whole brain analyses were performed using the statistical parametric mapping (SPM2) software. Results: PTSD patients had lower [11C]GR205171 binding compared to controls, in frontal cortical clusters encompassing bilaterally insula and left Brodmann area 11, reflecting lower NK1-receptor availability. No areas were found in which PTSD patients had higher [11C]GR205171 binding. Conclusions: This is the first study reporting differences in NK1-receptor availability in PTSD patients relative to controls. A tentative conclusion is that PTSD patients have a down regulation of the NK1-receptor system, which could be either a risk factor or due to emotional trauma processing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Psychiatry
- Psykiatri
- Psychology
- Psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
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