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S-system parameter ...
S-system parameter estimation for noisy metabolic profiles using Newton-flow analysis
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Kutalic, Zoltan (författare)
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- Tucker, Warwick (författare)
- Uppsala universitet,Matematiska institutionen
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Moulton, Vincent (författare)
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(creator_code:org_t)
- Institution of Engineering and Technology (IET), 2007
- 2007
- Engelska.
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Ingår i: IET Systems Biology. - : Institution of Engineering and Technology (IET). - 1751-8849 .- 1751-8857. ; 1:3, s. 174-180
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biochemical systems are commonly modelled by systems of ordinary differentialequations (ODEs). A particular class of such models called S-systems have recently gained popu-larity in biochemical system modelling. The parameters of an S-system are usually estimated fromtime-course profiles. However, finding these estimates is a difficult computational problem.Moreover, although several methods have been recently proposed to solve this problem for idealprofiles, relatively little progress has been reported for noisy profiles. We describe a specialfeature of a Newton-flow optimisation problem associated with S-system parameter estimation.This enables us to significantly reduce the search space, and also lends itself to parameter esti-mation for noisy data. We illustrate the applicability of our method by applying it to noisy time-course data synthetically produced from previously published 4- and 30-dimensional S-systems.In addition, we propose an extension of our method that allows the detection of network topologiesfor small S-systems. We introduce a new method for estimating S-system parameters from time-course profiles. We show that the performance of this method compares favorably with competingmethods for ideal profiles, and that it also allows the determination of parameters for noisy profiles.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Biology
- Biologi
Publikations- och innehållstyp
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