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No evidence of asso...
No evidence of association of the PDCD1 gene with Type 1 diabetes
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Fawwaz, S. (författare)
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- Nikamo, P. (författare)
- Karolinska Institutet
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Törn, C. (författare)
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Landin-Olsson, M. (författare)
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Lernmark, A. (författare)
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- Alarcón-Riquelme, Marta (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Kockum, I. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 24:12, s. 1473-1477
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims: To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods: Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738. Results: We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association. Conclusions: We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.
Nyckelord
- association
- autoimmunity
- PDCD1
- Type 1 diabetes
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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