Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma

• Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.

Nyckelord

Aged

Biological Markers/analysis

Cell Movement

Disease-Free Survival

Female

Humans

Immunohistochemistry

Lymphoma; Large B-Cell; Diffuse/*immunology

Male

Mast Cells/enzymology/*pathology

Middle Aged

Prognosis

Proportional Hazards Models

Statistics; Nonparametric

Survival Analysis

Tryptases/analysis

MEDICINE

MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)