Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge

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Mary, KämpeUppsala universitet,Lungmedicin och allergologi,Asthma Research Centre (författare)

Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge

Artikel/kapitelEngelska2011

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2011-01-21
Springer Science and Business Media LLC,2011
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-131538
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131538URI
https://doi.org/10.1186/1476-7961-9-3DOI

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Språk:engelska
Sammanfattning på:engelska

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Background:Patients with allergic rhinitis and allergic asthma demonstrate comparable local and systemic eosinophil inflammation, and yet they present with different clinical pictures. Less is even known about the contribution of neutrophil inflammation in allergic diseases. The aim of the study was to examine the propensity and selectivity of granule release from primed systemic eosinophils and neutrophils in allergic rhinitis and allergic asthma after seasonal and experimental allergen exposure. We hypothesize that the dissimilar clinical manifestations are due to diverse eosinophil and neutrophil degranulation. Methods: Nine birch pollen allergic patients with rhinitis, eight with asthma and four controls were studied during pollen season and after nasal and bronchial allergen challenge. Eosinophils and neutrophils were incubated in vitro with assay buffer and opsonized Sephadex particles for spontaneous and C3b-induced granule protein release. The released amount of eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) was measured by specific radioimmunoassay.Results:C3b-induced degranulation resulted in increased release of ECP and MPO from primed blood eosinophils and neutrophils in both allergic rhinitis and allergic asthma during pollen season and after both nasal and bronchial challenge (p-values 0.008 to 0.043). After bronchial challenge, the ECP release was significantly higher in the rhinitic group compared to the asthmatic group [19.8 vs. 13.2 %, (p=0.010)]. The propensity for EPO release was weak in all challenge models but followed the same pattern in both allergic groups.Conclusion: Systemically allergen primed eosinophils and neutrophils have similar patterns of degranulation after allergen exposure in allergic rhinitis and allergic asthma. The released amount of ECP, EPO and MPO was similar in all allergen challenge models in both allergic groups. Our results indicate that other mechanisms than the magnitude of eosinophil and neutrophil inflammation or the degranulation pattern of the inflammatory cells determines whether or not an allergic patient develops asthma.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
eosinophil degranulation
allergic asthma
allergic rhinitis
birch pollen allergy
Lung diseases
Lungsjukdomar
Lungmedicin
Lung Medicine

Biuppslag (personer, institutioner, konferenser, titlar ...)

Stolt, IngridUppsala universitet,Gastroenterologi/hepatologi,Gastroenterology Research Group, Asthma Research Centre(Swepub:uu)ingrstol (författare)
Lampinen, MariaUppsala universitet,Gastroenterologi/hepatologi,Gastroenterology Research Group, Asthma Research Centre(Swepub:uu)marilamp (författare)
Janson, ChristerUppsala universitet,Lungmedicin och allergologi,Asthma Research Centre(Swepub:uu)chrisjn (författare)
Stålenheim, GunnemarUppsala universitet,Lungmedicin och allergologi,Asthma Research Centre(Swepub:uu)gunnstal (författare)
Carlson, Marie,1957-Uppsala universitet,Gastroenterologi/hepatologi,Gastroenterology Research Group, Asthma Research Centre(Swepub:uu)maricarl (författare)
Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical and Molecular Allergy: Springer Science and Business Media LLC9:1, s. 3-1476-7961

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Clinical and Molecular Allergy (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Mary, Kämpe; Stolt, Ingrid; Lampinen, Maria; Janson, Christer; Stålenheim, Gunn ...; Carlson, Marie, ...

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