Sökning: onr:"swepub:oai:DiVA.org:uu-131876" >
Gastric Emptying an...
Gastric Emptying and Postprandial PYY Response After Biliopancreatic Diversion with Duodenal Switch
-
- Hedberg, Jakob (författare)
- Uppsala universitet,Gastrointestinalkirurgi
-
- Hedenström, Hans (författare)
- Uppsala universitet,Klinisk fysiologi,Klinisk Fysiologi
-
- Karlsson, F. Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism
-
visa fler...
-
- Edén-Engström, Britt (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism
-
- Sundbom, Magnus (författare)
- Uppsala universitet,Gastrointestinalkirurgi
-
visa färre...
-
(creator_code:org_t)
- 2010-09-23
- 2011
- Engelska.
-
Ingår i: Obesity Surgery. - : Springer Science and Business Media LLC. - 0960-8923 .- 1708-0428. ; 21:5, s. 609-615
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Super-obesity (BMI > 50) is increasing rapidly. We use the biliopancreatic diversion with duodenal switch (BPD-DS) as one option in this patient category. The aim of the present study was to investigate the emptying of the gastric tube, PYY levels and dumping symptoms after BPD-DS. METHODS: Emptying of the gastric tube was investigated with scintigraphy after an overnight fast. Twenty patients (median age 43 years, BMI 31.1 kg/m(2)) having undergone BPD-DS in median 3.5 years previously were included in the scintigraphic study. A technetium-labelled omelette was ingested and scintigraphic evaluation of gastric emptying was undertaken. Ten of the patients also underwent PYY measurements after a standardised meal and were compared to nine non-operated age-matched normal weight controls, both in the fasting state and after the test meal. Frequency of dumping symptoms was evaluated in all patients. RESULTS: The half-emptying time was 28 ± 16 min. Lag phase was present in 30% of the patients. PYY levels were significantly higher in BPD-DS patients as compared to controls both in the fasting state (p < 0.001) and after the test meal (p < 0.001). Dumping symptoms were scarce and occurred in 17 of the 20 patients only few times yearly or less. CONCLUSIONS: Although the pylorus is preserved in BPD-DS, the stomach emptying is faster than in non-operated subjects. PYY levels are elevated in the fasting state after BPD-DS and a marked response to a test meal is seen, likely due to the rapid stimulation of intraluminal nutrients in the distal ileum. In spite of this, dumping symptoms are uncommon.
Nyckelord
- Duodenal switch
- Gastric emptying
- PYY
- Scintigraphy
- Morbid obesity
- Dumping
- Surgery
- Kirurgi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas