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- Hedberg, JakobUppsala universitet,Gastrointestinalkirurgi (författare)
Gastric Emptying and Postprandial PYY Response After Biliopancreatic Diversion with Duodenal Switch
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
- 2010-09-23
- Springer Science and Business Media LLC,2011
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-131876
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131876URI
- https://doi.org/10.1007/s11695-010-0288-7DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- BACKGROUND: Super-obesity (BMI > 50) is increasing rapidly. We use the biliopancreatic diversion with duodenal switch (BPD-DS) as one option in this patient category. The aim of the present study was to investigate the emptying of the gastric tube, PYY levels and dumping symptoms after BPD-DS. METHODS: Emptying of the gastric tube was investigated with scintigraphy after an overnight fast. Twenty patients (median age 43 years, BMI 31.1 kg/m(2)) having undergone BPD-DS in median 3.5 years previously were included in the scintigraphic study. A technetium-labelled omelette was ingested and scintigraphic evaluation of gastric emptying was undertaken. Ten of the patients also underwent PYY measurements after a standardised meal and were compared to nine non-operated age-matched normal weight controls, both in the fasting state and after the test meal. Frequency of dumping symptoms was evaluated in all patients. RESULTS: The half-emptying time was 28 ± 16 min. Lag phase was present in 30% of the patients. PYY levels were significantly higher in BPD-DS patients as compared to controls both in the fasting state (p < 0.001) and after the test meal (p < 0.001). Dumping symptoms were scarce and occurred in 17 of the 20 patients only few times yearly or less. CONCLUSIONS: Although the pylorus is preserved in BPD-DS, the stomach emptying is faster than in non-operated subjects. PYY levels are elevated in the fasting state after BPD-DS and a marked response to a test meal is seen, likely due to the rapid stimulation of intraluminal nutrients in the distal ileum. In spite of this, dumping symptoms are uncommon.
Ämnesord och genrebeteckningar
- Duodenal switch
- Gastric emptying
- PYY
- Scintigraphy
- Morbid obesity
- Dumping
- Surgery
- Kirurgi
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Hedenström, HansUppsala universitet,Klinisk fysiologi,Klinisk Fysiologi(Swepub:uu)hanshede (författare)
- Karlsson, F. AndersUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism(Swepub:uu)anderska (författare)
- Edén-Engström, BrittUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism (författare)
- Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (författare)
- Uppsala universitetGastrointestinalkirurgi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Obesity Surgery: Springer Science and Business Media LLC21:5, s. 609-6150960-89231708-0428
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- Hedberg, Jakob
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- Sundbom, Magnus
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- Obesity Surgery
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- Uppsala universitet
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