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Ryanodine receptor-...
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Gustafsson, Amanda Jabin
(författare)
Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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2004-11-30
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Wiley,2005
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-132280
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132280URI
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https://doi.org/10.1096/fj.04-2621fjeDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1955170URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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There is little information available concerning the link between the ryanodine (RY) receptors and the downstream Ca(2+) signaling events in beta-cells. In fura-2 loaded INS-1E cells, activation of RY receptors by 9-methyl 5,7-dibromoeudistomin D (MBED) caused a rapid rise of [Ca(2+)]i followed by a plateau and repetitive [Ca(2+)]i spikes on the plateau. The [Ca(2+)]i plateau was abolished by omission of extracellular Ca(2+) and by SKF 96365. In the presence of SKF 96365, MBED produced a transient increase of [Ca(2+)]i, which was abolished by thapsigargin. Activation of RY receptors caused Ca(2+) entry even when the ER Ca(2+) pool was depleted by thapsigargin. The [Ca(2+)]i plateau was not inhibited by nimodipine or ruthenium red, but was inhibited by membrane depolarization, La(3+), Gd(3+), niflumic acid, and 2-aminoethoxydiphenyl borate, agents that inhibit the transient receptor potential channels. The [Ca(2+)]i spikes were inhibited by nimodipine and ryanodine, indicating that they were due to Ca(2+) influx through the voltage-gated Ca(2+) channels and Ca(2+)-induced Ca(2+) release (CICR). Activation of RY receptors depolarized membrane potential as measured by patch clamp. Thus, activation of RY receptors leads to coherent changes in Ca(2+) signaling, which includes activation of TRP-like channels, membrane depolarization, activation of the voltage-gated Ca(2+) channels and CICR.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ingelman-Sundberg, Hanna
(författare)
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Dzabic, MensurKarolinska Institutet
(författare)
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Awasum, Justina
(författare)
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Nguyen, Khanh Hoa
(författare)
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Östenson, Claes-GöranKarolinska Institutet
(författare)
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Pierro, Cristina
(författare)
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Tedeschi, Patrizia
(författare)
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Woolcott, Orison
(författare)
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Chiounan, ShiueKarolinska Institutet
(författare)
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Lund, Per-Eric
(författare)
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Larsson, Olof
(författare)
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Islam, M. ShahidulKarolinska Institutet,Uppsala universitet,Medicin
(författare)
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Karolinska InstitutetMedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The FASEB Journal: Wiley19:2, s. 301-3030892-66381530-6860
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Gustafsson, Aman ...
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Ingelman-Sundber ...
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Dzabic, Mensur
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Awasum, Justina
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Nguyen, Khanh Ho ...
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Östenson, Claes- ...
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Pierro, Cristina
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Tedeschi, Patriz ...
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Woolcott, Orison
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Chiounan, Shiue
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Lund, Per-Eric
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Larsson, Olof
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Islam, M. Shahid ...
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The FASEB Journa ...
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Uppsala universitet
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Karolinska Institutet