Sökning: onr:"swepub:oai:DiVA.org:uu-133959" >
Epstein-Barr virus ...
Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
-
Yenamandra, Surya Pavan (författare)
-
- Hellman, Ulf (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
-
Kempkes, Bettina (författare)
-
visa fler...
-
- Darekar, Suhas Deoram (författare)
- Karolinska Institutet
-
Petermann, Sabine (författare)
-
Sculley, Tom (författare)
-
- Klein, George (författare)
- Karolinska Institutet
-
- Kashuba, Elena (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2010-07-01
- 2010
- Engelska.
-
Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 67:24, s. 4249-4256
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.
Nyckelord
- EBV
- VDR
- Transcription regulation
- EBNA
- Vitamin D3
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas