Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants

Rytter, Elisabet,1960-Uppsala universitet,Oxidativ stress och inflammation,Klinisk nutrition och metabolism (författare)

The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Antioxidants
oxidative stress
isoprostanes
lipid peroxidation
DNA damage
overweight
MEDICINE
MEDICIN
Nutrition
Nutrition

Johansson, ClaraKarolinska Institutet,Department of Biosciences and Nutrition, Karolinska Institute (författare)
Vessby, BengtUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)bengvess (författare)
Sjödin, AndersDepartment of Human Nutrition, Faculty of Life Science, University of Copenhagen (författare)
Möller, LennartKarolinska Institutet,Department of Biosciences and Nutrition, Karolinska Institute (författare)
Åkesson, BjörnLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Department of Pure and Applied Biochemistry, Biomedical Nutrition, Lunds University(Swepub:lu)kc-bak (författare)
Basu, SamarUppsala universitet,Oxidativ stress och inflammation(Swepub:uu)samabasu (författare)
Uppsala universitetOxidativ stress och inflammation (creator_code:org_t)

Ingår i:Free radical research: Informa UK Limited44:5, s. 522-5281071-57621029-2470

Av författaren/redakt...: Rytter, Elisabet ...; Johansson, Clara; Vessby, Bengt; Sjödin, Anders; Möller, Lennart; Åkesson, Björn; visa fler...; Basu, Samar; visa färre...

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