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Low levels of IgM a...
Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men : Effects on uptake of oxidized LDL in macrophages as a potential mechanism
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- de Faire, Ulf (författare)
- Karolinska Institutet
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Su, Jun (författare)
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Hua, Xiang (författare)
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- Frostegård, Anna (författare)
- Karolinska Institutet
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- Halldin, Mats (författare)
- Karolinska Institutet
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- Hellenius, Mai-Lis (författare)
- Karolinska Institutet
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Wikström, Max (författare)
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- Dahlbom, Ingrid (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall
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- Grönlund, Hans (författare)
- Karolinska Institutet
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- Frostegård, Johan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411 .- 1095-9157. ; 34:2, s. 73-79
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). Methods: From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ischemic stroke, or hospitalized angina pectoris) and 633 age- and sex-matched controls were identified through a 5-7 year follow-up. Serum levels of IgM anti-PC was determined by ELISA. Anti-PC was extracted from pooled human IgM and the effect of anti-PC on the uptake of OxLDL was studied by FACScan. Results: Relative risks (RR) with 95% confidence intervals (Cl) by quartiles of anti-PC levels with quartile 4 set as the reference value (RR = 1.0) and adjusted for smoking, BMI, type 11 diabetes, hypercholesterolaemia, and high blood pressure yielded an excess risk for CVD only for those within the lowest quartile of anti-PC values with an RR of 1.37 (CI 0.87-2.16). However, for men stronger associations were noted with increasing multivariately adjusted RRs from quartile 4 to quartile 1. Subjects within quartile I (values below 29.7 U/ml) had a significantly increased RR of 1.96 (Cl 1.09-3.55). Further adjustments for hsCRP gave essentially the same results. No excess risk was noted for women. Specific anti-PC could be extracted from IgM and these antibodies inhibited macrophage uptake of OxLDL Conclusions: Low IgM anti-PC could be a novel risk marker for CVD among men. One possible mechanism could be inhibition of uptake of oxLDL in macrophages.
Nyckelord
- Atherosclerosis
- Innate immunity
- Natural antibodies
- Phosphorylcholine
- Cardiovascular disease
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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de Faire, Ulf
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Su, Jun
-
Hua, Xiang
-
Frostegård, Anna
-
Halldin, Mats
-
Hellenius, Mai-L ...
-
visa fler...
-
Wikström, Max
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Dahlbom, Ingrid
-
Grönlund, Hans
-
Frostegård, Joha ...
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visa färre...
- Artiklar i publikationen
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Journal of Autoi ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet