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Transcapillary exch...
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Reed, Rolf K.
(författare)
Transcapillary exchange : role and importance of the interstitial fluid pressure and the extracellular matrix
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-05-13
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Oxford University Press (OUP),2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-137727
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137727URI
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https://doi.org/10.1093/cvr/cvq143DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P-if) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P-if can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P-if include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P-if and restore the normal compaction of the ECM. The magnitude of the lowering of P-if varies with the inflammatory response. In several inflammatory reactions, a lowering of P-if to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P-if is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability.
Ämnesord och genrebeteckningar
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Connective tissue
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beta-Integrin receptors
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Glycosaminoglycans
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Inflammation
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rubin, KristoferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)krisrubi
(författare)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cardiovascular Research: Oxford University Press (OUP)87:2, s. 211-2170008-63631755-3245
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