Sökning: onr:"swepub:oai:DiVA.org:uu-143661" > Expression Analysis...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02952naa a2200517 4500 | |
001 | oai:DiVA.org:uu-143661 | |
003 | SwePub | |
008 | 110124s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1436612 URI |
024 | 7 | a https://doi.org/10.1002/mc.206922 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Meunier, Dominique4 aut |
245 | 1 0 | a Expression Analysis of Proline Rich 15 (Prr15) in Mouse and Human Gastrointestinal Tumors |
264 | c 2010-11-08 | |
264 | 1 | b Wiley,c 2011 |
338 | a print2 rdacarrier | |
520 | a Proline rich 15 (Prr15), which encodes a protein of unknown function, is expressed almost exclusively in postmitotic cells both during fetal development and in adult tissues, such as the intestinal epithelium and the testis. To determine if this specific expression is lost in intestinal neoplasias, we examined Prr15 expression by in situ hybridization (ISH) on mouse intestinal tumors caused by different gene mutations, and on human colorectal cancer (CRC) samples. Prr15/PRR15 expression was consistently observed in mouse gastrointestinal (GI) tumors caused by mutations in the Apc gene, as well as in several advanced stage human CRCs. In contrast, no Prr15 expression was detected in intestinal tumors derived from mice carrying mutations in the Smad3, Smad4, or Cdkn1b genes. These findings, combined with the fact that a majority of sporadic human CRCs carry APC mutations, strongly suggest that the expression of Prr15/PRR15 in mouse and human GI tumors is linked, directly or indirectly, to the absence of the APC protein or, more generally, to the disruption of the Wnt signaling pathway. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a proline rich 15 | |
653 | a Prr15 | |
653 | a Apc | |
653 | a intestinal neoplasia | |
653 | a colorectal cancer | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a Biology | |
653 | a Biologi | |
700 | 1 | a Patra, Kalicharanu Uppsala universitet,Evolution och utvecklingsbiologi4 aut |
700 | 1 | a Smits, Ron4 aut |
700 | 1 | a Haegebarth, Andrea4 aut |
700 | 1 | a Luettges, Angela4 aut |
700 | 1 | a Jaussi, Rolf4 aut |
700 | 1 | a Wieduwilt, Matthew J.4 aut |
700 | 1 | a Quintanilla-Fend, Leticia4 aut |
700 | 1 | a Himmelbauer, Heinz4 aut |
700 | 1 | a Fodde, Riccardo4 aut |
700 | 1 | a Fundele, Reinald H.u Uppsala universitet,Evolution och utvecklingsbiologi4 aut |
710 | 2 | a Uppsala universitetb Evolution och utvecklingsbiologi4 org |
773 | 0 | t Molecular Carcinogenesisd : Wileyg 50:1, s. 8-15q 50:1<8-15x 0899-1987x 1098-2744 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143661 |
856 | 4 8 | u https://doi.org/10.1002/mc.20692 |
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