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Well-Tolerated Chem...
Well-Tolerated Chemoprophylaxis Uniformly Prevented Swedish Soldiers from Plasmodium falciparum Malaria in Liberia, 2004-2006
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Andersson, Håkan (författare)
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- Askling, Helena H. (författare)
- Karolinska Institutet
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Falck, Björn (författare)
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- Rombo, Lars (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i D län (CKFD)
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Military medicine. - 0026-4075 .- 1930-613X. ; 173:12, s. 1194-1198
- Relaterad länk:
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Background: Between 2004 and 2006, 1,170 Swedish soldiers were deployed to Liberia. They were prescribed mefloquine or atovaquone/proguanil as malaria chemoprophylaxis. Our study aims were to estimate the chemoprophylaxis effectiveness and adverse events. Methods: Cases of malaria were routinely reported during and after the mission. After return to Sweden, the soldiers filled in a questionnaire concerning type of accommodation, use of prophylaxis, and adverse events. Results: No cases of Plasmodium falciparum malaria were recorded during a total of 7,000 person-months. Adverse events (AE) were reported by 57% in the mefloquine group and 34% in the atovaquone/proguanil group. In the mefloquine group, the soldiers reported more neuropsychological AE. Conclusions: Both drugs were safe and 100% effective as lone-term prophylaxis for prevention of P. falciparum malaria. Atovaquone/proguanil was better tolerated with respect to self-reported AE.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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