Sökning: onr:"swepub:oai:DiVA.org:uu-150059" >
Acquired aplastic a...
-
Honkaniemi, EmmaKarolinska Institutet
(författare)
Acquired aplastic anaemia in seven children with severe hepatitis with or without liver failure
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
-
Wiley,2007
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-150059
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150059URI
-
https://doi.org/10.1111/j.1651-2227.2007.00491.xDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:116105905URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Aim: Aplastic anaemia following hepatitis may develop in as many as 1 of 3 patients with non-A, non-B and non-C hepatitis. Several causative factors have been discussed, such as viral infections and autoimmunity. Here we describe the natural history of this condition in 7 children and investigate possible hepatitis-causing agents. Methods: We reviewed the medical records, bone marrow and liver biopsies of 7 children with severe hepatitis, with or without liver failure, who subsequently had developed aplastic anaemia. Results: The median time from onset of hepatic symptoms until diagnosed onset of aplasia was 54 days. No associated viral infections could be identified. On liver biopsy, a majority had lobular inflammation but lacked signs of autoimmune hepatitis, findings compatible with a viral aetiology. Three of 6 children had low reticulocyte counts already at onset of hepatitis. All, but one patient is alive at median follow-up of 8 years. Conclusion: The unknown pathogenetic mechanism appears to target liver and bone marrow simultaneously, because half of the children concomitantly had low reticulocyte counts and severe liver failure.
Ämnesord och genrebeteckningar
-
aplastic anaemia
-
hepatitis
-
liver failure
-
virus infection
-
MEDICINE
-
MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Gustafsson, BrittKarolinska Institutet
(författare)
-
Fischler, BjörnKarolinska Institutet
(författare)
-
Nemeth, AntalKarolinska Institutet
(författare)
-
Frost, Britt-MarieUppsala universitet,Pediatrik(Swepub:uu)brittfo
(författare)
-
Papadogiannakis, NikosKarolinska Institutet
(författare)
-
Winiarski, JacekKarolinska Institutet
(författare)
-
Karolinska InstitutetPediatrik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Acta Paediatrica: Wiley96:11, s. 1660-16640803-52531651-2227
Internetlänk
Hitta via bibliotek
Till lärosätets databas