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On the Feasibility ...
On the Feasibility of Nanocrystal Imaging Using Intense and Ultrashort X-ray Pulses
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Caleman, Carl (författare)
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- Huldt, Gösta (författare)
- Uppsala universitet,Molekylär biofysik
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- Maia, Filipe R. N. C. (författare)
- Uppsala universitet,Molekylär biofysik
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Ortiz, Carlos (författare)
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Parak, Fritz G. (författare)
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- Hajdu, Janos (författare)
- Uppsala universitet,Molekylär biofysik
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- van der Spoel, David (författare)
- Uppsala universitet,Beräknings- och systembiologi
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Chapman, Henry N. (författare)
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- Timneanu, Nicusor (författare)
- Uppsala universitet,Molekylär biofysik
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(creator_code:org_t)
- 2010-12-07
- 2011
- Engelska.
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Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 5:1, s. 139-146
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Structural studies of biological macromolecules are severely limited by radiation damage. Traditional crystallography curbs the effects of damage by spreading damage over many copies of the molecule of interest in the crystal. X-ray lasers offer an additional opportunity for limiting damage by out-running damage processes with ultrashort and very intense X-ray pulses Such pulses may allow the imaging of single molecules, clusters; Or nanoparticles: Coherent flash Imaging Will also open up new avenues for structural studies on nano- and microcrystalline substances. This paper addresses the theoretical potentials and limitations of nanocrystallography with extremely intense coherent X-ray pulses. We use urea nanocrystals as a model for generic biological substances and simulate the primary and secondary ionization dynamics in the crystalline sample. The results establish conditions for ultrafast single shot nanocrystallography diffraction experiments as a function of X-ray fluence, pulse duration, and the size of nanocrystals. Nanocrystallography using ultrafast X-ray pulses has the potential to open up a new route in protein crystallography to solve atomic structures of many systems that remain Inaccessible using conventional X-ray sources.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- X-ray free electron laser
- nanocrystallography
- radiation damage
- molecular dynamics
- coherent diffraction imaging
- Biology
- Biologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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ACS Nano
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