CUBN Is a Gene Locus for Albuminuria

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Fältnamn	Indikatorer	Metadata
000		07561naa a2201753 4500
001		oai:DiVA.org:uu-151658
003		SwePub
008		110415s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:122240148
009		oai:dalea.du.se:5794
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1516582 URI
024	7	a https://doi.org/10.1681/ASN.20100605982 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1222401482 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:du-57942 URI
040		a (SwePub)uud (SwePub)kid (SwePub)du
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Boeger, Carsten A.4 aut
245	1 0	a CUBN Is a Gene Locus for Albuminuria
264	1	c 2011
338		a print2 rdacarrier
520		a Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 x 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a MEDICINE
653		a MEDICIN
653		a Hälsa och välfärd
700	1	a Chen, Ming-Huei4 aut
700	1	a Tin, Adrienne4 aut
700	1	a Olden, Matthias4 aut
700	1	a Koettgen, Anna4 aut
700	1	a de Boer, Ian H.4 aut
700	1	a Fuchsberger, Christian4 aut
700	1	a O'Seaghdha, Conall M.4 aut
700	1	a Pattaro, Cristian4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Liu, Ching-Ti4 aut
700	1	a Glazer, Nicole L.4 aut
700	1	a Li, Man4 aut
700	1	a O'Conne, Jeffrey R.4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Peralta, Carmen A.4 aut
700	1	a Kutalik, Zoltan4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Hwang, Shih-Jen4 aut
700	1	a Akylbekova, Ermeg4 aut
700	1	a Kramer, Holly4 aut
700	1	a van der Harst, Pim4 aut
700	1	a Smith, Albert V.4 aut
700	1	a Lohman, Kurt4 aut
700	1	a de Andrade, Mariza4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Kollerits, Barbara4 aut
700	1	a Toenjes, Anke4 aut
700	1	a Aspelund, Thor4 aut
700	1	a Ingelsson, Eriku Karolinska Institutet4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Shuldiner, Alan R.4 aut
700	1	a Mitchell, Braxton D.4 aut
700	1	a Arking, Dan E.4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Egan, Josephine4 aut
700	1	a Hernandez, Dena4 aut
700	1	a Reilly, Muredach4 aut
700	1	a Townsend, Raymond R.4 aut
700	1	a Lumley, Thomas4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Kestenbaum, Bryan4 aut
700	1	a Haritunians, Talin4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gerard4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Waterworth, Dawn4 aut
700	1	a Johnson, Andrew D.4 aut
700	1	a Florez, Jose C.4 aut
700	1	a Meigs, James B.4 aut
700	1	a Lu, Xiaoning4 aut
700	1	a Turner, Stephen T.4 aut
700	1	a Atkinson, Elizabeth J.4 aut
700	1	a Leak, Tennille S.4 aut
700	1	a Aasarod, Knut4 aut
700	1	a Skorpen, Frank4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva
700	1	a Illig, Thomas4 aut
700	1	a Baumert, Jens4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Kraemer, Bernhard K.4 aut
700	1	a Devuyst, Olivier4 aut
700	1	a Mychaleckyj, Josyf C.4 aut
700	1	a Minelli, Cosetta4 aut
700	1	a Bakker, Stephan J. L.4 aut
700	1	a Kedenko, Lyudmyla4 aut
700	1	a Paulweber, Bernhard4 aut
700	1	a Coassin, Stefan4 aut
700	1	a Endlich, Karlhans4 aut
700	1	a Kroemer, Heyo K.4 aut
700	1	a Biffar, Reiner4 aut
700	1	a Stracke, Sylvia4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Stumvol, Michael4 aut
700	1	a Maegi, Reedik4 aut
700	1	a Campbell, Harry4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Hastie, Nicholas D.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Kardia, Sharon L. R.4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Curhan, Gary4 aut
700	1	a Kronenberg, Florian4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Rudan, Igor4 aut
700	1	a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap4 aut0 (Swepub:du)jan
700	1	a Hallan, Stein4 aut
700	1	a Navis, Gerjan4 aut
700	1	a Parsa, Afshin4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Coresh, Josef4 aut
700	1	a Shlipak, Michael G.4 aut
700	1	a Bul, Shelley B.4 aut
700	1	a Paterson, Andrew D.4 aut
700	1	a Wichmann, H. -Erich4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Loos, Ruth J. F.4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Pramstaller, Peter P.4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a Beckmann, Jacques S.4 aut
700	1	a Yang, Qiong4 aut
700	1	a Heid, Iris M.4 aut
700	1	a Rettig, Rainer4 aut
700	1	a Dreisbach, Albert W.4 aut
700	1	a Bochud, Murielle4 aut
700	1	a Fox, Caroline S.4 aut
700	1	a Kao, W. H. L.4 aut
710	2	a Karolinska Institutetb Molekylär medicin4 org
773	0	t Journal of the American Society of Nephrologyg 22:3, s. 555-570q 22:3<555-570x 1046-6673x 1533-3450
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151658
856	4 8	u https://doi.org/10.1681/ASN.2010060598
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122240148
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:du-5794

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Av författaren/redakt...: Boeger, Carsten ...; Chen, Ming-Huei; Tin, Adrienne; Olden, Matthias; Koettgen, Anna; de Boer, Ian H.; visa fler...; Fuchsberger, Chr ...; O'Seaghdha, Cona ...; Pattaro, Cristia ...; Teumer, Alexande ...; Liu, Ching-Ti; Glazer, Nicole L ...; Li, Man; O'Conne, Jeffrey ...; Tanaka, Toshiko; Peralta, Carmen ...; Kutalik, Zoltan; Luan, Jian'an; Zhao, Jing Hua; Hwang, Shih-Jen; Akylbekova, Erme ...; Kramer, Holly; van der Harst, P ...; Smith, Albert V.; Lohman, Kurt; de Andrade, Mari ...; Hayward, Carolin ...; Kollerits, Barba ...; Toenjes, Anke; Aspelund, Thor; Ingelsson, Erik; Eiriksdottir, Gu ...; Launer, Lenore J ...; Harris, Tamara B ...; Shuldiner, Alan ...; Mitchell, Braxto ...; Arking, Dan E.; Franceschini, No ...; Boerwinkle, Eric; Egan, Josephine; Hernandez, Dena; Reilly, Muredach; Townsend, Raymon ...; Lumley, Thomas; Siscovick, David ...; Psaty, Bruce M.; Kestenbaum, Brya ...; Haritunians, Tal ...; Bergmann, Sven; Vollenweider, Pe ...; Waeber, Gerard; Mooser, Vincent; Waterworth, Dawn; Johnson, Andrew ...; Florez, Jose C.; Meigs, James B.; Lu, Xiaoning; Turner, Stephen ...; Atkinson, Elizab ...; Leak, Tennille S ...; Aasarod, Knut; Skorpen, Frank; Syvänen, Ann-Chr ...; Illig, Thomas; Baumert, Jens; Koenig, Wolfgang; Kraemer, Bernhar ...; Devuyst, Olivier; Mychaleckyj, Jos ...; Minelli, Cosetta; Bakker, Stephan ...; Kedenko, Lyudmyl ...; Paulweber, Bernh ...; Coassin, Stefan; Endlich, Karlhan ...; Kroemer, Heyo K.; Biffar, Reiner; Stracke, Sylvia; Voelzke, Henry; Stumvol, Michael; Maegi, Reedik; Campbell, Harry; Vitart, Veroniqu ...; Hastie, Nicholas ...; Gudnason, Vilmun ...; Kardia, Sharon L ...; Liu, Yongmei; Polasek, Ozren; Curhan, Gary; Kronenberg, Flor ...; Prokopenko, Inga; Rudan, Igor; Ärnlöv, Johan; Hallan, Stein; Navis, Gerjan; Parsa, Afshin; Ferrucci, Luigi; Coresh, Josef; Shlipak, Michael ...; Bul, Shelley B.; Paterson, Andrew ...; Wichmann, H. -Er ...; Wareham, Nichola ...; Loos, Ruth J. F.; Rotter, Jerome I ...; Pramstaller, Pet ...; Cupples, L. Adri ...; Beckmann, Jacque ...; Yang, Qiong; Heid, Iris M.; Rettig, Rainer; Dreisbach, Alber ...; Bochud, Murielle; Fox, Caroline S.; Kao, W. H. L.; visa färre...

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