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Older Men With Low ...
Older Men With Low Serum IGF-1 Have an Increased Risk of Incident Fractures : The MrOS Sweden Study
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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- Mellström, Dan, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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- Carlzon, Daniel (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Orwoll, Eric (författare)
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- Ljunggren, Östen (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Karlsson, Magnus (författare)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Vandenput, Liesbeth, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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(creator_code:org_t)
- 2011-03-23
- 2011
- Engelska.
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Ingår i: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431 .- 1523-4681. ; 26:4, s. 865-872
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Osteoporosis-related fractures constitute a major health concern not only in women but also in men. Insulin-like growth factor 1 (IGF-1) is a key determinant of bone mass, but the association between serum IGF-1 and incident fractures in men remains unclear. To determine the predictive value of serum IGF-1 for fracture risk in men, older men (n = 2902, mean age of 75 years) participating in the prospective, population-based Osteoporotic Fractures in Men (MrOS) Sweden study were followed for a mean of 3.3 years. Serum IGF-1 was measured at baseline by radioimmunoassay. Fractures occurring after the baseline visit were validated. In age-adjusted hazards regression analyses, serum IGF-1 associated inversely with risk of all fractures [hazard ratio (HR) per SD decrease = 1.23, 95% confidence interval (CI) 1.07-1.41], hip fractures (HR per SD decrease = 1.45, 95% CI 1.07-1.97), and clinical vertebral fractures (HR per SD decrease = 1.40, 95% CI 1.10-1-78). The predictive role of serum IGF-1 for fracture risk was unaffected by adjustment for height, weight, prevalent fractures, falls, and major prevalent diseases. Further adjustment for bone mineral density (BMD) resulted in an attenuated but still significant association between serum IGF-1 and fracture risk. Serum IGF-1 below but not above the median was inversely related to fracture incidence. The population-attributable risk proportion was 7.5% for all fractures and 22.9% for hip fractures. Taken together, older men with low serum IGF-1 have an increased fracture risk, especially for the two most important fracture types, hip and vertebral fractures. The association between serum IGF-1 and fracture risk is partly mediated via BMD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- POPULATION STUDIES
- INSULIN-LIKE GROWTH FACTOR 1
- AGING
- MEN
- FRACTURE
- MEDICINE
- MEDICIN
- POPULATION STUDIES
- INSULIN-LIKE GROWTH FACTOR 1
- AGING
- MEN
- FRACTURE
- POPULATION STUDIES; INSULIN-LIKE GROWTH FACTOR 1; AGING; MEN; FRACTURE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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