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Hepatic and extrahe...
Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients
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- Werner, Mårten (författare)
- Umeå universitet,Medicin,Umeå University Hospital
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Prytz, Hanne (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital
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- Lindgren, Stefan (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Malmö University Hospital
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- Wallerstedt, Sven (författare)
- Karolinska University Hospital
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Björnsson, Einar (författare)
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- Bergquist, Annika (författare)
- Karolinska Institutet
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- Sandberg-Gertzen, Hanna (författare)
- Örebro University Hospital
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Sangfelt, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University Hospital
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- Weiland, Ola (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Danielsson, Åke (författare)
- Umeå universitet,Medicin,Umeå University Hospital
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Journal of Hepatology. - : Elsevier BV. - 0168-8278 .- 1600-0641. ; 50:2, s. 388-393
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients. Methods: Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register. Results: We found an overall higher risk of malignancies in the cohort of A I H patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and complete case finding was 23.28 (95% CI 7.5-54.34) for HCC. Lymphomas were found a SIR of 13.09 (95% CI 4.22-30.56). Conclusions: There was an overall increased risk of malignancies in a cohort of AIH patients, which manly was caused by hepatobiliary cancers. However, the true risk of HCC in an AIH cirrhotic cohort has yet to be investigated. A significantly higher risk of lymphomas was also found, but no clear cut association to the use of immune modulators.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Autoimmune hepatitis
- Hepatocellular carcinoma
- Lymphoma
- Malignancies
- MEDICINE
- MEDICIN
- Malignancies
- Lymphoma
- Autoimmune hepatitis
- Hepatocellular carcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Werner, Mårten
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Almer, Sven
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Prytz, Hanne
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Lindgren, Stefan
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Wallerstedt, Sve ...
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Björnsson, Einar
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visa fler...
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Bergquist, Annik ...
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Sandberg-Gertzen ...
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Hultcrantz, Rolf
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Sangfelt, Per
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Weiland, Ola
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Danielsson, Åke
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Journal of Hepat ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet
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Linköpings universitet