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Chemotherapeutic ta...
Chemotherapeutic targeting of microtubules causes epidermal growth factor receptor dephosphorylation
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- Wu, Xuping (författare)
- Uppsala universitet,Enheten för onkologi
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- Lennartsson, Johan (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Bergström, Stefan (författare)
- Uppsala universitet,Enheten för onkologi
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visa fler...
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- Bergqvist, Michael (författare)
- Uppsala universitet,Enheten för onkologi
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- Gullbo, Joachim (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Ekman, Simon (författare)
- Uppsala universitet,Enheten för onkologi
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Microtubules are important structures for a range of cellular functions including cell division. Drugs that interfere with microtubule function can prevent cells from mitosis and various microtubule targeting drugs are used in a clinical setting. In the current study we investigated the sensitivity of oesophageal cancer cells to different microtubule targeting agents. As expected, experiments demonstrated that these agents in a dose-dependent manner inhibited survival and proliferation of oesophageal cancer cells and disrupted the microtubule network. Unexpectedly, experiments showed that microtubule destabilising agents inhibited phosphorylation and activation of the EGF-receptor, and that a tyrosine phosphatase inhibitor, sodium orthovanadate, could reverse the EGFR dephosphorylation. We propose a model in which disruption of the microtubule network leads to activation of a protein tyrosine phosphatase that can regulate EGFR phosphorylation and activation, indicating an additional mechanism of action of microtubule targeting agents.
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- vet (ämneskategori)
- art (ämneskategori)
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