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Exogenous carbon mo...
Exogenous carbon monoxide does not affect cell membrane energy availability assessed by sarcolemmal calcium fluxes during myocardial ischaemia-reperfusion in the pig
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- Ahlström, Katarina, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Biber, Björn, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Åberg, Anna-Maja (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Abrahamsson, Pernilla (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Ronquist, Gunnar (författare)
- Uppsala universitet,Institutionen för läkemedelskemi,Department of Medical Chemistry, Uppsala University, Uppsala, Sweden
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- Waldenström, Anders (författare)
- Umeå universitet,Kardiologi
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- Haney, Michael F. (författare)
- Umeå universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: European Journal of Anaesthesiology. - 0265-0215 .- 1365-2346. ; 28:5, s. 356-362
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Carbon monoxide is thought to be cytoprotective and may hold therapeutic promise for mitigating ischaemic injury. The purpose of this study was to test low-dose carbon monoxide for protective effects in a porcine model of acute myocardial ischaemia and reperfusion. In acute open-thorax experiments in anaesthetised pigs, pretreatment with low-dose carbon monoxide (5% increase in carboxyhaemoglobin) was conducted for 120 min before localised ischaemia (45 min) and reperfusion (60 min) was performed using a coronary snare. Metabolic and injury markers were collected by microdialysis sampling in the ventricular wall. Recovery of radio-marked calcium delivered locally by microperfusate was measured to assess carbon monoxide treatment effects during ischaemia/reperfusion on the intracellular calcium pool. Coronary occlusion and ischaemia/reperfusion were analysed for 16 animals (eight in each group). Changes in glucose, lactate and pyruvate from the ischaemic area were observed during ischaemia and reperfusion interventions, though there was no difference between carbon monoxide-treated and control groups during ischaemia or reperfusion. Similar results were observed for glycerol and microdialysate Ca-45(2+) recovery. These findings show that a relatively low and clinically relevant dose of carbon monoxide did not seem to provide acute protection as indicated by metabolic, energy-related and injury markers in a porcine myocardial ischaemia/reperfusion experimental model. We conclude that protective effects of carbon monoxide related to ischaemia/reperfusion either require higher doses of carbon monoxide or occur later after reperfusion than the immediate time frame studied here. More study is needed to characterise the mechanism and time frame of carbon monoxide-related cytoprotection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- calcium
- carbon monoxide
- myocardial ischaemia
- preconditioning
- reperfusion
- swine
- MEDICINE
- MEDICIN
- Calcium; Carbon monoxide; Myocardial ischaemia; Preconditioning; Reperfusion; Swine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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