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Positron emission t...
Positron emission tomography with 11C-D-deprenyl in patients with rheumatoid arthritis. Evaluation of knee joint inflammation before and after intra-articular glucocorticoid treatment
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- Danfors, Torsten (författare)
- Uppsala universitet,Medicin
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- Bergström, M (författare)
- Uppsala University PET Centre, University Hospital, Uppsala, Sweden
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- Feltelius, N (författare)
- Uppsala universitet,Medicin
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Westerberg, G (författare)
- Uppsala University PET Centre, University Hospital, Uppsala, Sweden
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- Långström, Bengt (författare)
- Uppsala University PET Centre, University Hospital, Uppsala, Sweden
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 26:1, s. 43-48
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Seven patients with arthritic disease and with clinical signs of inflammation of the knee joint, were investigated with positron emission tomography (PET) after injection of [N-methyl-11C]-D-deprenyl. Two healthy volunteers were included as controls. In five patients the investigation was repeated after an intra-articular injection of glucocorticoids. All patients showed very high uptake of the tracer in the paraarticular structures of the joint. After treatment there was approximately a 50% reduction of the uptake in the treated knees, both in the high uptake regions and in the surrounding soft tissues. No change was observed in the non-treated knees. In the healthy volunteers, only soft tissue surrounding the joint showed an uptake of the tracer, but at a magnitude which was 6-8 times lower than the high uptake regions in the arthritis patients. Although the mechanisms for the high uptake of 11C-D-deprenyl in affected joints of patients with arthritis is not clear, the present work points to a potential of PET for the assessment of disease intensity and monitoring of treatment.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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