Sökning: onr:"swepub:oai:DiVA.org:uu-153606" > The presence of rhe...
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000 | 04810naa a2200505 4500 | |
001 | oai:DiVA.org:uu-153606 | |
003 | SwePub | |
008 | 110516s2011 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:be083207-7393-4691-84f8-8b53fbdf329d | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1536062 URI |
024 | 7 | a https://doi.org/10.3109/03009742.2010.5091032 DOI |
024 | 7 | a https://lup.lub.lu.se/record/18681532 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nyhäll-Wåhlin, B-M4 aut |
245 | 1 0 | a The presence of rheumatoid nodules at early rheumatoid arthritis diagnosis is a sign of extra-articular disease and predicts radiographic progression of joint destruction over 5 years |
264 | c 2010-10-05 | |
264 | 1 | b Informa UK Limited,c 2011 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: Radiographic damage is an important outcome in rheumatoid arthritis (RA). The disease course varies considerably, and there is a need for simple and reliable prognostic markers. The aim of the study was to determine the utility of early signs of extra-articular disease, manifested as rheumatoid nodules (RN), in predicting radiographic outcome. METHODS: In a cohort (n = 1589) of consecutive, newly diagnosed patients with RA, 112 cases with RN at inclusion (7%) were identified. Each case was compared to two age- and sex-matched controls without nodules from the same cohort. Radiographs of the hands and feet were performed at inclusion, after 1, 2, and 5 years and scored according to the modified Sharp van der Heijde Score (SHS; range 0-448). RESULTS: Fifty-two cases with RN and 139 controls without RN had available radiographs at baseline and after 5 years. Cases were more often rheumatoid factor (RF) positive and anti-cyclic citrullinated peptide (anti-CCP) positive, and had higher disease activity and radiographic damage scores at baseline (7.9 vs. 2.5). After 5 years, there was more extensive radiographic damage among the cases (mean SHS progression 21.7 vs. 13.5). In bivariate analysis, positive RF, positive anti-CCP, SHS, and RN were strong baseline predictors for radiographic progression up to 5 years. In multivariate analysis, positive anti-CCP and SHS at baseline were independently associated with radiographic progression. CONCLUSION: The presence of RN at baseline is a marker of extra-articular involvement and severe disease, and a predictor of subsequent joint damage. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a Rheumatoid arthritis | |
653 | a ACPA | |
653 | a prognosis | |
653 | a Rheumatology | |
653 | a Reumatologi | |
700 | 1 | a Turesson, Carlu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ctn |
700 | 1 | a Jacobsson, Lennartu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)orto-lja |
700 | 1 | a Nilsson, Jan-Åkeu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Enheten för led- och mjukvävnadsforskning,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Joint and Soft Tissue Unit4 aut0 (Swepub:lu)med-jnn |
700 | 1 | a Forslind, K4 aut |
700 | 1 | a Albertsson, K4 aut |
700 | 1 | a Rönnelid, Johanu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)joharonn |
700 | 1 | a Petersson, Ingemaru Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ipe |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Scandinavian journal of rheumatologyd : Informa UK Limitedg 40:2, s. 81-87q 40:2<81-87x 0300-9742x 1502-7732 |
856 | 4 | u https://lup.lub.lu.se/search/files/1996748/1894761.pdf |
856 | 4 | u https://portal.research.lu.se/files/1996748/1894761.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.3109/03009742.2010.509103y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153606 |
856 | 4 8 | u https://doi.org/10.3109/03009742.2010.509103 |
856 | 4 8 | u https://lup.lub.lu.se/record/1868153 |
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