Sökning: onr:"swepub:oai:DiVA.org:uu-155810" >
Dendritic cell expr...
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue
-
Alcaide, Pilar (författare)
-
Jones, Tatiana G (författare)
-
Lord, Graham M (författare)
-
visa fler...
-
Glimcher, Laurie H (författare)
-
- Hallgren, Jenny (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
Arinobu, Yojiro (författare)
-
Akashi, Koichi (författare)
-
Paterson, Alison M (författare)
-
Gurish, Michael A (författare)
-
Luscinskas, Francis W (författare)
-
visa färre...
-
(creator_code:org_t)
- 2007-02-12
- 2007
- Engelska.
-
Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 204:2, s. 431-439
- Relaterad länk:
-
http://jem.rupress.o...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The transcription factor T-bet was identified in CD4(+) T cells, and it controls interferon gamma production and T helper type 1 cell differentiation. T-bet is expressed in certain other leukocytes, and we recently showed (Lord, G.M., R.M. Rao, H. Choe, B.M. Sullivan, A.H. Lichtman, F.W. Luscinskas, and L.H. Glimcher. 2005. Blood. 106:3432-3439) that it regulates T cell trafficking. We examined whether T-bet influences homing of mast cell progenitors (MCp) to peripheral tissues. Surprisingly, we found that MCp homing to the lung or small intestine in T-bet(-/-) mice is reduced. This is reproduced in adhesion studies using bone marrow-derived MCs (BMMCs) from T-bet(-/-) mice, which showed diminished adhesion to mucosal addresin cellular adhesion molecule-1 (MAdCAM-1) and vascular cell adhesion molecule-1 (VCAM-1), endothelial ligands required for MCp intestinal homing. MCp, their precursors, and BMMCs do not express T-bet, suggesting that T-bet plays an indirect role in homing. However, adoptive transfer experiments revealed that T-bet expression by BM cells is required for MCp homing to the intestine. Furthermore, transfer of WT BM-derived dendritic cells (DCs) to T-bet(-/-) mice restores normal MCp intestinal homing in vivo and MCp adhesion to MAdCAM-1 and VCAM-1 in vitro. Nonetheless, T-bet(-/-) mice respond vigorously to intestinal infection with Trichinella spiralis, eliminating a role for T-bet in MC recruitment to sites of infection and their activation and function. Therefore, remarkably, T-bet expression by DCs indirectly controls MCp homing to mucosal tissues.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Alcaide, Pilar
-
Jones, Tatiana G
-
Lord, Graham M
-
Glimcher, Laurie ...
-
Hallgren, Jenny
-
Arinobu, Yojiro
-
visa fler...
-
Akashi, Koichi
-
Paterson, Alison ...
-
Gurish, Michael ...
-
Luscinskas, Fran ...
-
visa färre...
- Artiklar i publikationen
-
Journal of Exper ...
- Av lärosätet
-
Uppsala universitet