In Vivo Evaluation of Functionalized Biomimetic Hydroxyapatite for Local Delivery of Active Agents

• This study was carried out to investigate the biological response in vivo to biomimetic hydroxyapatite implant coatings functionalized with bisphosphonates and bone morphogenetic proteins. The functionalization was carried out by a simple soaking procedure in the operating room immediately prior to surgery. Cylindrical titanium samples with and without coatings were implanted in the distal femoral epiphysis of sheep and retrieved after 6 weeks. The histological analysis proved that all samples were integrated well in the tissue with no signs of intolerance. Fewer osteoclasts were observed in the vicinity of bisphosphonate-functionalized samples and the bone was denser around these samples compared to the other samples. Samples functionalized with bone morphogenetic protein induced more bone/implant contact but showed a more inconsistent outcome with reduced bone density around the samples. This study demonstrates a simple method to functionalize implant coatings, which provides surgeons with an option of patient-specific functionalization of implants. The observed biological impact due to the delivery of active molecules from the coatings suggests that this strategy may also be employed to deliver antibiotics from similar coatings.

Ämnesord

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Nyckelord

TECHNOLOGY

TEKNIKVETENSKAP

Polymer chemistry

Polymerkemi

Engineering Science with specialization in Materials Science

Teknisk fysik med inriktning mot materialvetenskap

Teknisk fysik med inriktning mot nanoteknologi och funktionella material

Engineering Science with specialization in Nanotechnology and Functional Materials

Chemistry with specialization in Polymer Chemistry

Kemi med inriktning mot polymerkemi

Publikations- och innehållstyp

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