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Activation of perox...
Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
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- Risérus, Ulf (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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Sprecher, Dennis (författare)
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Johnson, Tony (författare)
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visa fler...
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Olson, Eric (författare)
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Hirschberg, Sandra (författare)
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Liu, Aixue (författare)
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Fang, Zeke (författare)
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Hegde, Priti (författare)
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Richards, Duncan (författare)
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Sarov-Blat, Leli (författare)
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Strum, Jay C (författare)
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- Basu, Samar (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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Cheeseman, Jane (författare)
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Fielding, Barbara A (författare)
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Humphreys, Sandy M (författare)
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Danoff, Theodore (författare)
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Moore, Niall R (författare)
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Murgatroyd, Peter (författare)
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O'Rahilly, Stephen (författare)
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Sutton, Pauline (författare)
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Willson, Tim (författare)
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Hassall, David (författare)
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Frayn, Keith N (författare)
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Karpe, Fredrik (författare)
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(creator_code:org_t)
- American Diabetes Association, 2008
- 2008
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 57:2, s. 332-339
- Relaterad länk:
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https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIEVE-Pharmacological use of peroxisome proliferator-activated receptor (PPAR)delta agonists and transgenic overexpression of PPAR delta in mice suggest amelioration of features of the metabolic syndrome through enhanced fat oxidation in skeletal muscle. We hypothesize a similar mechanism operates in humans. RESEARCH DESIGN AND METHODS-The PPAR delta agonist (10 mg o.d. GW501516), a comparator PPAR alpha agonist (20 mu g o.d. GW590735)), and placebo were given in a double-blind, randomized, three-parallel group, 2-week study to six healthy moderately overweight subjects in each group. Metabolic evaluation was made before and after treatment including liver fat quantification, fasting blood samples, a 6-h meal tolerance test with stable isotope fatty acids, skeletal muscle biopsy for gene expression, and urinary isoprostanes for global oxidative stress. RESULTS-Treatment with GW501516 showed statistically significant reductions in fasting plasma triglycerides (-30%), apolipoprotein B (-26%), LDL cholesterol (-23%), and insulin (-11%), whereas HDL cholesterol was unchanged. A 20% reduction in liver fat content (P < 0.05) and 30% reduction in urinary isoprostanes (P = 0.01) were also observed. Except for a lowering of triglycerides (-30%, P < 0.05), none of these changes were observed in response to GW590735. The relative proportion of exhaled CO, directly originating from the fat content of the meal was increased (P < 0.05) in response to GW501516, and skeletal muscle expression of carnitine palmitoyl-transferase 1b (CPT1b) was also significantly increased. CONCLUSIONS-The PPAR delta agonist GW501516 reverses multiple abnormalities associated with the metabolic syndrome without increasing oxidative stress. The effect is probably caused by increased fat oxidation in skeletal muscle.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Risérus, Ulf
-
Sprecher, Dennis
-
Johnson, Tony
-
Olson, Eric
-
Hirschberg, Sand ...
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Liu, Aixue
-
visa fler...
-
Fang, Zeke
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Hegde, Priti
-
Richards, Duncan
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Sarov-Blat, Leli
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Strum, Jay C
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Basu, Samar
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Cheeseman, Jane
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Fielding, Barbar ...
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Humphreys, Sandy ...
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Danoff, Theodore
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Moore, Niall R
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Murgatroyd, Pete ...
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O'Rahilly, Steph ...
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Sutton, Pauline
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Willson, Tim
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Hassall, David
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Frayn, Keith N
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Karpe, Fredrik
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visa färre...
- Artiklar i publikationen
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Diabetes
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Uppsala universitet