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Expression of inter...
Expression of interferon-gamma in human adrenal gland and kidney tumours
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Li, Q. (författare)
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- Zhang, Xiao-Qun (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Nie, L. (författare)
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Chen, G-S (författare)
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Li, H. (författare)
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Zhang, F. (författare)
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Zhang, L-Y (författare)
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Hong, L. (författare)
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Wang, S-F (författare)
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Wang, H. (författare)
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(creator_code:org_t)
- 2007-07-10
- 2007
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 97:3, s. 420-425
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- It is known that interferon-γ (IFN-γ) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-γ-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human tumour cells can produce IFN-γ, we examined 429 biopsy specimens of 30 kinds of tumour and tumour-surrounding tissues in adrenal glands and in kidneys by using immunohistochemistry and in situ hybridisation. IFN-γ immunoactivity was shown in 34.3% of the adrenal cortical adenomas, 50% of the adrenal cortical carcinomas, 26.7% of the phaeochromocytomas, 26.7% of the clear cell renal cell carcinomas (RCCs), 22% of the adrenal cortexes and 40% of medullas adjacent to tumours. The positive samples and expression areas were well overlapped between the IFN-γ mRNA and the immunohistochemistry staining. Western blot analysis has further confirmed the immunohistochemistry results by showing a distinct IFN-γ band corresponding to 17.4 kDa in tissue extracts from adrenal cortical adenoma, phaeochromocytoma and clear cell RCCs. These results indicate that IFN-γ is produced by some types of tumour cells, suggesting it may play a dual role in the development of these tumours.
Nyckelord
- Adrenal tumour
- Clear cell renal cell carcinoma
- Interferon-γ
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Li, Q.
-
Zhang, Xiao-Qun
-
Nie, L.
-
Chen, G-S
-
Li, H.
-
Zhang, F.
-
visa fler...
-
Zhang, L-Y
-
Hong, L.
-
Wang, S-F
-
Wang, H.
-
visa färre...
- Artiklar i publikationen
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British Journal ...
- Av lärosätet
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Uppsala universitet