Sökning: onr:"swepub:oai:DiVA.org:uu-157849" > Evolution of pathog...
Fältnamn | Indikatorer | Metadata |
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000 | 03954naa a2200865 4500 | |
001 | oai:DiVA.org:uu-157849 | |
003 | SwePub | |
008 | 110823s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1578492 URI |
024 | 7 | a https://doi.org/10.1038/nature080642 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Butler, Geraldine4 aut |
245 | 1 0 | a Evolution of pathogenicity and sexual reproduction in eight Candida genomes. |
264 | c 2009-05-24 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
338 | a print2 rdacarrier | |
520 | a Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes. | |
700 | 1 | a Rasmussen, Matthew D4 aut |
700 | 1 | a Lin, Michael F4 aut |
700 | 1 | a Santos, Manuel A S4 aut |
700 | 1 | a Sakthikumar, Sharadha4 aut |
700 | 1 | a Munro, Carol A4 aut |
700 | 1 | a Rheinbay, Esther4 aut |
700 | 1 | a Grabherr, Manfred4 aut |
700 | 1 | a Forche, Anja4 aut |
700 | 1 | a Reedy, Jennifer L4 aut |
700 | 1 | a Agrafioti, Ino4 aut |
700 | 1 | a Arnaud, Martha B4 aut |
700 | 1 | a Bates, Steven4 aut |
700 | 1 | a Brown, Alistair J P4 aut |
700 | 1 | a Brunke, Sascha4 aut |
700 | 1 | a Costanzo, Maria C4 aut |
700 | 1 | a Fitzpatrick, David A4 aut |
700 | 1 | a de Groot, Piet W J4 aut |
700 | 1 | a Harris, David4 aut |
700 | 1 | a Hoyer, Lois L4 aut |
700 | 1 | a Hube, Bernhard4 aut |
700 | 1 | a Klis, Frans M4 aut |
700 | 1 | a Kodira, Chinnappa4 aut |
700 | 1 | a Lennard, Nicola4 aut |
700 | 1 | a Logue, Mary E4 aut |
700 | 1 | a Martin, Ronny4 aut |
700 | 1 | a Neiman, Aaron M4 aut |
700 | 1 | a Nikolaou, Elissavet4 aut |
700 | 1 | a Quail, Michael A4 aut |
700 | 1 | a Quinn, Janet4 aut |
700 | 1 | a Santos, Maria C4 aut |
700 | 1 | a Schmitzberger, Florian F4 aut |
700 | 1 | a Sherlock, Gavin4 aut |
700 | 1 | a Shah, Prachi4 aut |
700 | 1 | a Silverstein, Kevin A T4 aut |
700 | 1 | a Skrzypek, Marek S4 aut |
700 | 1 | a Soll, David4 aut |
700 | 1 | a Staggs, Rodney4 aut |
700 | 1 | a Stansfield, Ian4 aut |
700 | 1 | a Stumpf, Michael P H4 aut |
700 | 1 | a Sudbery, Peter E4 aut |
700 | 1 | a Srikantha, Thyagarajan4 aut |
700 | 1 | a Zeng, Qiandong4 aut |
700 | 1 | a Berman, Judith4 aut |
700 | 1 | a Berriman, Matthew4 aut |
700 | 1 | a Heitman, Joseph4 aut |
700 | 1 | a Gow, Neil A R4 aut |
700 | 1 | a Lorenz, Michael C4 aut |
700 | 1 | a Birren, Bruce W4 aut |
700 | 1 | a Kellis, Manolis4 aut |
700 | 1 | a Cuomo, Christina A4 aut |
773 | 0 | t Natured : Springer Science and Business Media LLCg 459:7247, s. 657-62q 459:7247<657-62x 1476-4687x 0028-0836 |
856 | 4 | u https://www.nature.com/articles/nature08064.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157849 |
856 | 4 8 | u https://doi.org/10.1038/nature08064 |
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