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Development of abdo...
Development of abdominal fat and incipient metabolic syndrome in young healthy men exposed to long-term stress
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- Branth, Stefan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Ronquist, Gunnar (författare)
- Uppsala universitet,Klinisk kemi
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- Stridsberg, Mats (författare)
- Uppsala universitet,Klinisk kemi
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- Hambraeus, Leif (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Kindgren, Erik (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Olsson, Roger (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Carlander, David (författare)
- Uppsala universitet,Klinisk kemi,Biologisk struktur och funktion
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- Arnetz, Bengt (författare)
- Uppsala universitet,Socialmedicin
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 17:6, s. 427-435
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND AIM: The sympathetic nervous system may be involved in the pathophysiology of insulin resistance and metabolic cardiovascular syndrome in young men. The aim was to study the effects of long-term stress on different features of the metabolic syndrome (MES) in formerly non-obese healthy young males during 5 months of defined conditions. METHODS AND RESULTS: Sixteen healthy male sailors (mean age 36.5 (SD)+/-7 years) participating in a sailing race around the world were recruited for the study. Investigations were done before the start and at stop overs after finishing laps 1, 2 and 4 (1, 2(1/2) and 5 months, respectively). Anthropometric and blood pressure data as well as biochemical data associated with MES were substantiated. Food intake and exercise were chartered and largely controlled. A mean weight loss of 4.5+/-2 kg (P<0.005), comprising both fat and lean body mass, was recorded during the first lap. Subsequently after 5 months, a weight gain, mainly consisting of 1.2+/-1.1 kg body fat (P<0.05), took place, concomitantly with a protein mass drop of 0.6+/-1.1 kg (P<0.05). The body fat gain accumulated on the abdominal region. Elevated blood levels of HbA1c, insulin and the triglycerides/high-density lipoprotein ratio were also observed during the race. Likewise heart rate and systolic blood pressure increased slightly but to a statistically significant extent. CONCLUSIONS: Non-obese healthy young men exposed to long-term stress developed abdominal obesity and signs of a metabolic syndrome in embryo, also emphasized by biochemical and blood pressure alterations. It is suggested that long-term and sustained stress activation might be an additional risk factor for the development of MES, even after control of dietary and exercise habits.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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