Painless drug delivery through microneedle-based transdermal patches featuring active infusion

QC 20100624
This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mul/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.

Samel, BjörnKTH,Mikrosystemteknik(Swepub:kth)u12nzcir (författare)
Nordquist, Lina,1977-Uppsala universitet,Integrativ Fysiologi,Nordquist,Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University(Swepub:uu)linor172 (författare)
Griss, PatrickZühlke Engineering AG, Zurich(Swepub:kth)u1phxkgl (författare)
Stemme, GöranKTH,Mikrosystemteknik(Swepub:kth)u1oyebfq (författare)
KTHMikrosystemteknik (creator_code:org_t)

Ingår i:IEEE Transactions on Biomedical Engineering55:3, s. 1063-10710018-92941558-2531

Av författaren/redakt...: Roxhed, Niclas; Samel, Björn; Nordquist, Lina, ...; Griss, Patrick; Stemme, Göran

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk labora ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.